2-[nitroso(phenyl)amino]acetohydrazide | 948897-99-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[nitroso(phenyl)amino]acetohydrazide
• 英文别名: N-(2-hydrazinyl-2-oxoethyl)-N-phenylnitrous amide
• CAS: 948897-99-2
• 化学式: C₈H₁₀N₄O₂
• 分子量: 194.193
• InChiKey: YIFHPHNHAZZQNM-UHFFFAOYSA-N

物化性质

• 熔点：
  115 °C(Solvent: Ethanol)
• 沸点：
  480.3±37.0 °C(predicted)
• 密度：
  1.34±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  草酸醛 、 2-[nitroso(phenyl)amino]acetohydrazide 以 乙醇 为溶剂， 反应 4.0h， 以87%的产率得到2-(N-nitrosoanilino)-N-[2-[[2-(N-nitrosoanilino)acetyl]hydrazinylidene]ethylideneamino]acetamide
  参考文献：
  名称：

  Transition metal complexes of a new hexadentate macroacyclic N2O4-donor Schiff base: Inhibitory activity against bacteria and fungi

  摘要：

  A new hexadentate macroacyclic N2O4 - donor ligand, glyoxal bis(N-nitroso phenylglycine) (gbnp), has been designed and structurally characterized. Manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes of gbnp have been prepared and characterized by elemental analyses, molar conductance measurements, magnetic moment, spectral (IR, H-1 NMR, electronic and FAB mass) and thermal studies. The molecular dynamics of the ligand was studied by the variable temperature NMR studies, which suggest the presence of two isomeric forms. The antimicrobial activity of all the compounds was studied against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Candida albicans. Among the new complexes, copper(II) complex has the highest potential against all the microorganisms tested. (c) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.03.025
• 作为产物：
  描述：

  N-ethoxycarbonylmethyl-N-nitrosoaniline 在 肼 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 以82%的产率得到2-[nitroso(phenyl)amino]acetohydrazide
  参考文献：
  名称：

  Transition metal complexes of a new hexadentate macroacyclic N2O4-donor Schiff base: Inhibitory activity against bacteria and fungi

  摘要：

  A new hexadentate macroacyclic N2O4 - donor ligand, glyoxal bis(N-nitroso phenylglycine) (gbnp), has been designed and structurally characterized. Manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes of gbnp have been prepared and characterized by elemental analyses, molar conductance measurements, magnetic moment, spectral (IR, H-1 NMR, electronic and FAB mass) and thermal studies. The molecular dynamics of the ligand was studied by the variable temperature NMR studies, which suggest the presence of two isomeric forms. The antimicrobial activity of all the compounds was studied against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Candida albicans. Among the new complexes, copper(II) complex has the highest potential against all the microorganisms tested. (c) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.03.025

文献信息

• Transition metal complexes of a new hexadentate macroacyclic N2O4-donor Schiff base: Inhibitory activity against bacteria and fungi
  作者：Manjula Patil、Rekha Hunoor、Kalagouda Gudasi

  DOI：10.1016/j.ejmech.2010.03.025

  日期：2010.7

  A new hexadentate macroacyclic N2O4 - donor ligand, glyoxal bis(N-nitroso phenylglycine) (gbnp), has been designed and structurally characterized. Manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes of gbnp have been prepared and characterized by elemental analyses, molar conductance measurements, magnetic moment, spectral (IR, H-1 NMR, electronic and FAB mass) and thermal studies. The molecular dynamics of the ligand was studied by the variable temperature NMR studies, which suggest the presence of two isomeric forms. The antimicrobial activity of all the compounds was studied against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Candida albicans. Among the new complexes, copper(II) complex has the highest potential against all the microorganisms tested. (c) 2010 Elsevier Masson SAS. All rights reserved.