N-tert-Butyloxycarbonyl-dl-azidoalanine | 108283-49-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-tert-Butyloxycarbonyl-dl-azidoalanine
• 英文别名: (2S)-2-[azido-[(2-methylpropan-2-yl)oxycarbonyl]amino]propanoic acid
• CAS: 108283-49-4；958802-96-5
• 化学式: C8H14N4O4
• mdl: MFCD18252751
• 分子量: 230.22
• InChiKey: NOAOACNYCMDXCJ-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  81.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-tert-Butyloxycarbonyl-dl-azidoalanine 、 溴甲苯 、 N,N-二异丙基乙胺 在 ethyl acetate n-hexane 、 溴甲苯 作用下， 以 乙腈 、 ethyl acetate n-hexane 为溶剂， 反应 18.0h， 生成 Boc-Azidoalanine benzyl ester
  参考文献：
  名称：

  PHOSPHOHISTIDINE ANALOGS

  摘要：

  本发明涉及公式（I）的磷酸组氨酸类似物以及含有同样残基的半抗原。本发明还涉及与载体分子结合的半抗原和针对免疫原的分离抗体，所述抗体识别含有磷酸化组氨酸或磷酸三唑残基的多肽，但不识别未磷酸化的氨基酸或多肽，也不识别在组氨酸以外的氨基酸上磷酸化但未在组氨酸上磷酸化的多肽。

  公开号：

  US20130260398A1

文献信息

• PHOSPHOHISTIDINE ANALOGS
  申请人：Muir Tom W.

  公开号：US20130260398A1

  公开（公告）日：2013-10-03

  The present invention relates to the phosphohistidine analogs of the present invention which of the formula (I) and the hapten containing the residue of same. It also relates to the hapten conjugated to a carrier molecule and the isolated antibodies raised against the immunogens, said antibodies recognizing polypeptide containing a phosphorylated histidine or the phosphotriazole residue but it does not recognize an amino acid or polypeptide that is not phosphorylated or a polypeptide which is phosphorylated on amino acids other than histidine but not on histidine.

  本发明涉及公式（I）的磷酸组氨酸类似物以及含有同样残基的半抗原。本发明还涉及与载体分子结合的半抗原和针对免疫原的分离抗体，所述抗体识别含有磷酸化组氨酸或磷酸三唑残基的多肽，但不识别未磷酸化的氨基酸或多肽，也不识别在组氨酸以外的氨基酸上磷酸化但未在组氨酸上磷酸化的多肽。
• US9035068B2
  申请人：——

  公开号：US9035068B2

  公开（公告）日：2015-05-19
• US9765154B2
  申请人：——

  公开号：US9765154B2

  公开（公告）日：2017-09-19
• [EN] PHOSPHOHISTIDINE ANALOGS<br/>[FR] ANALOGUES DE PHOSPHOHISTIDINE
  申请人：UNIV ROCKEFELLER

  公开号：WO2012040523A2

  公开（公告）日：2012-03-29

  The present invention relates to the phosphohistidine analogs of the present invention which of the formula (I) and the hapten containing the residue of same. It also relates to the hapten conjugated to a carrier molecule and the isolated antibodies raised against the immunogens, said antibodies recognizing polypeptide containing a phosphorylated histidine or the phosphotriazole residue but it does not recognize an amino acid or polypeptide that is not phosphorylated or a polypeptide which is phosphorylated on amino acids other than histidine but not on histidine.
• Phosphohistidine analogs
  申请人：Muir Tom W.

  公开号：US09035068B2

  公开（公告）日：2015-05-19

  The present invention relates to the phosphohistidine analogs of the present invention which of the formula (I) and the hapten containing the residue of same. It also relates to the hapten conjugated to a carrier molecule and the isolated antibodies raised against the immunogens, said antibodies recognizing polypeptide containing a phosphorylated histidine or the phosphotriazole residue but it does not recognize an amino acid or polypeptide that is not phosphorylated or a polypeptide which is phosphorylated on amino acids other than histidine but not on histidine.

  本发明涉及公式（I）的磷酸组氨酸类似物以及含有相同残基的半抗原。本发明还涉及与载体分子结合的半抗原和对免疫原产生的孤立抗体，所述抗体识别含有磷酸化组氨酸或磷酸三唑残基的多肽，但不识别未磷酸化的氨基酸或多肽，也不识别磷酸化在组氨酸以外的氨基酸上但不磷酸化组氨酸的多肽。