(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enoic acid
• 化学式: C₁₂H₂₂O₆
• 分子量: 262.3
• InChiKey: ZFHWVPYQOYZQED-UTINFBMNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED LACTAMS AND THEIR USE AS ANTI-CANCER AGENTS<br/>[FR] LACTAMES SUBSTITUES ET UTILISATION DE CEUX-CI EN TANT QU'AGENTS ANTI-CANCEREUX
  申请人：NOVARTIS AG

  公开号：WO2005014574A1

  公开（公告）日：2005-02-17

  This invention relates to certain substituted lactam compounds of the formula (I), particularly caprolactam compounds, which are useful for the treatment of cancer.

  本发明涉及公式（I）的某些取代内酰胺化合物，特别是己内酰胺化合物，其用于治疗癌症。
• Substituted lactams and their use as anti-cancer agents
  申请人：Bair Kenneth Walter

  公开号：US20060281731A1

  公开（公告）日：2006-12-14

  This invention relates to certain substituted lactam compounds of the formula (I), particularly caprolactam compounds, which are useful for the treatment of cancer.

  本发明涉及某些式(I)的取代内酰胺化合物，特别是己内酰胺化合物，其对癌症的治疗有用。
• Substituted Lactams and Their Use as Anti-Cancer Agents
  申请人：Bair Kenneth Walter

  公开号：US20080275025A1

  公开（公告）日：2008-11-06

  This invention relates to certain substituted lactam compounds, particularly caprolactam compounds, which are useful for the treatment of cancer.

  本发明涉及某些取代的内酰胺化合物，特别是己内酰胺化合物，其对于癌症的治疗是有用的。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• SUBSTITUTED LACTAMS AND THEIR USE AS ANTI-CANCER AGENTS
  申请人：Novartis AG

  公开号：EP1651633A1

  公开（公告）日：2006-05-03