2,3,5,6-tetrafluoro-4-hydroxy-N-[2-(prop-2-enoylamino)ethyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,5,6-tetrafluoro-4-hydroxy-N-[2-(prop-2-enoylamino)ethyl]benzamide
• 化学式: C₁₄H₄BrF₄O₃Pol
• 分子量: 306.21
• InChiKey: TVRKGHMIKIVNMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,3,5,6-tetrafluoro-4-hydroxy-N-[2-(prop-2-enoylamino)ethyl]benzamide 、 2-苯乙胺 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 4-bromo-N-phenethylbenzamide
  参考文献：
  名称：

  High throughput ‘catch-and-release’ synthesis within spatially discrete gel arrays

  摘要：

  A tetrafluorophenol acrylamide monomer unit was synthesised, co-polymerised and grafted onto a glass slide to form individual gel spots. As a proof of principle study, a small library of amides was rapidly synthesised within these gel spots using 'catch-and-release' chemistry, including the biologically interesting quorum sensing acyl-homoserine lactones. The tetrafluorophenol acrylamide gel provides an efficient platform to synthesise and screen small molecules for biological activity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.024
• 作为产物：
  描述：

  2,2-dimethyl-N-[2-(piperidin-1-yl)ethyl]propanamide 、 4-溴苯甲酰氯 在 吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 2,3,5,6-tetrafluoro-4-hydroxy-N-[2-(prop-2-enoylamino)ethyl]benzamide
  参考文献：
  名称：

  High throughput ‘catch-and-release’ synthesis within spatially discrete gel arrays

  摘要：

  A tetrafluorophenol acrylamide monomer unit was synthesised, co-polymerised and grafted onto a glass slide to form individual gel spots. As a proof of principle study, a small library of amides was rapidly synthesised within these gel spots using 'catch-and-release' chemistry, including the biologically interesting quorum sensing acyl-homoserine lactones. The tetrafluorophenol acrylamide gel provides an efficient platform to synthesise and screen small molecules for biological activity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.024

文献信息

• High throughput ‘catch-and-release’ synthesis within spatially discrete gel arrays
  作者：Christine M. Boehner、David M. Marsden、Hannah F. Sore、David Norton、David R. Spring

  DOI：10.1016/j.tetlet.2010.09.024

  日期：2010.11

  A tetrafluorophenol acrylamide monomer unit was synthesised, co-polymerised and grafted onto a glass slide to form individual gel spots. As a proof of principle study, a small library of amides was rapidly synthesised within these gel spots using 'catch-and-release' chemistry, including the biologically interesting quorum sensing acyl-homoserine lactones. The tetrafluorophenol acrylamide gel provides an efficient platform to synthesise and screen small molecules for biological activity. (C) 2010 Elsevier Ltd. All rights reserved.