trans-(D)-N^α-(Boc)-4-hydroxycyclohexylglycine | 130624-89-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: trans-(D)-N^α-(Boc)-4-hydroxycyclohexylglycine
• 英文别名: a-(Boc-amino)-4-hydroxycyclohexaneacetic acid；2-(4-hydroxycyclohexyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid
• CAS: 130624-89-4
• 化学式: C₁₃H₂₃NO₅
• 分子量: 273.329
• InChiKey: CFJDDDVVNKUBCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2924299090

反应信息

• 作为产物：
  描述：

  D(-)-对羟基苯甘氨酸 在 Ni-Raney 氢气 、 三乙胺 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 36.0h， 生成 trans-(D)-N^α-(Boc)-4-hydroxycyclohexylglycine
  参考文献：
  名称：

  Banfi, Aldo; Benedini, Francesca; Sala, Alberto, Synthetic Communications, 1990, vol. 20, # 22, p. 3585 - 3597

  摘要：

  DOI：

文献信息

• [EN] DIMERIC IAP INHIBITORS<br/>[FR] INHIBITEURS IAP DIMÉRIQUES
  申请人：NOVARTIS AG

  公开号：WO2012080271A1

  公开（公告）日：2012-06-21

  The present invention provides compounds of formula M-L-M' (where M and M' are each independently a monomeric moiety of Formula (I) and L is a linker). The dimeric compounds have been found to be effective in promoting apoptosis in rapidly dividing cells. (I)

  本发明提供了公式M-L-M'的化合物（其中M和M'分别独立地是公式（I）的单体基团，L是连接基团）。已发现二聚化合物在促进快速分裂细胞凋亡方面具有有效性。（I）
• Dipeptidyl peptidase-IV inhibitors
  申请人：Hulin Bernard

  公开号：US20050234065A1

  公开（公告）日：2005-10-20

  The invention provides compounds of Formula (I) or prodrugs thereof, or pharmaceutically acceptable salts of said compounds or prodrugs, or solvates of said compounds, prodrugs or salts, wherein A, N, X and R 1 are as defined herein; pharmaceutical compositions thereof; and methods of using the pharmaceutical compositions for the treatment of diseases, including Type 2 diabetes, Type 1 diabetes, impaired glucose tolerance, hyperglycemia, metabolic syndrome (syndrome X and/or insulin resistance syndrome), glucosuria, metabolic acidosis, arthritis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, obesity, conditions exacerbated by obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, short stature due to growth hormone deficiency, infertility due to polycystic ovary syndrome, anxiety, depression, insomnia, chronic fatigue, epilepsy, eating disorders, chronic pain, alcohol addiction, diseases associated with intestinal motility, ulcers, irritable bowel syndrome, inflammatory bowel syndrome; short bowel syndrome; and the prevention of disease progression in Type 2 diabetes.

  该发明提供了Formula (I)的化合物或其前药，或者该化合物或前药的药用可接受盐，或者该化合物、前药或盐的溶剂化合物，其中A、N、X和R1如本文所定义；以及这些药物组合物；以及使用这些药物组合物治疗疾病的方法，包括2型糖尿病、1型糖尿病、糖耐量受损、高血糖、代谢综合征（综合征X和/或胰岛素抵抗综合征）、葡萄糖尿病、代谢性酸中毒、关节炎、白内障、糖尿病神经病、糖尿病肾病、糖尿病视网膜病、糖尿病心肌病、肥胖、由肥胖恶化的疾病、高血压、高脂血症、动脉粥样硬化、骨质疏松症、脆弱、骨质流失、骨折、急性冠状动脉综合征、生长激素缺乏引起的矮小症、多囊卵巢综合征引起的不孕症、焦虑、抑郁、失眠、慢性疲劳、癫痫、进食障碍、慢性疼痛、酒精成瘾、与肠道蠕动相关的疾病、溃疡、肠易激综合征、炎症性肠病；短肠综合征；以及预防2型糖尿病疾病进展。
• [EN] FUSED INDOLES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES<br/>[FR] INDOLES FUSIONNES EN TANT QU'INHIBITEURS DE DIPEPTIDYLE PEPTIDASE DESTINES AU TRAITEMENT OU A LA PREVENTION DES DIABETES
  申请人：MERCK & CO INC

  公开号：WO2004110436A1

  公开（公告）日：2004-12-23

  The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及融合的吲哚衍生物，其是二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂，并且在治疗或预防二肽基肽酶-IV酶参与的疾病，如糖尿病和特别是2型糖尿病方面非常有用。本发明还涉及包含这些化合物的制药组合物，以及在预防或治疗二肽基肽酶-IV酶参与的这些疾病方面使用这些化合物和组合物。
• DIMERIC IAP INHIBITORS
  申请人：Straub Christopher Sean

  公开号：US20130266590A1

  公开（公告）日：2013-10-10

  The present invention provides compounds of formula M-L-M′ (where M and M′ are each independently a monomeric moiety of Formula (I), (II), (III) or (IV) and L is a linker). The dimeric compounds have been found to be effective in promoting apoptosis in rapidly dividing cells.

  本发明提供了公式M-L-M'的化合物（其中M和M'分别独立地是公式（I），（II），（III）或（IV）的单体基团，而L是连接基）。已经发现这些二聚化合物在促进快速分裂的细胞中的凋亡方面具有有效性。
• Banfi, Aldo; Benedini, Francesca; Sala, Alberto, Synthetic Communications, 1990, vol. 20, # 10, p. 1531 - 1542
  作者：Banfi, Aldo、Benedini, Francesca、Sala, Alberto

  DOI：——

  日期：——