4-bromo-2,3,5,6-tetrafluoro-4’-methoxyl-1,1’-biphenyl | 1262967-32-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-2,3,5,6-tetrafluoro-4’-methoxyl-1,1’-biphenyl
• 英文别名: 4-bromo-2,3,5,6-tetrafluoro-4'-methoxybiphenyl；4-bromo-2,3,5,6-tetrafluoro-4'-methoxy-1,1'-biphenyl；1-Bromo-2,3,5,6-tetrafluoro-4-(4-methoxyphenyl)benzene；1-bromo-2,3,5,6-tetrafluoro-4-(4-methoxyphenyl)benzene
• CAS: 1262967-32-7
• 化学式: C₁₃H₇BrF₄O
• 分子量: 335.096
• InChiKey: MZELRZZWMIIMFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-溴-2,3,5,6-四氟苯甲酸 、 4-甲氧基苯硼酸新戊二醇酯 在 palladium(II) trifluoroacetate 、 silver carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 2.0h， 以92%的产率得到4-bromo-2,3,5,6-tetrafluoro-4’-methoxyl-1,1’-biphenyl
  参考文献：
  名称：

  Pd催化的Suzuki脱羧反应和芳香族羧酸的正交Cu基O-芳基化反应。

  摘要：

  钯催化的脱羧Suzuki反应和芳香族羧酸的正交Cu基O-芳基化反应已有报道。新的反应可能为某些联芳基和芳族羧酸酯的合成提供替代途径。

  DOI：

  10.1039/c0cc04104a

文献信息

• Palladium-Catalyzed Direct Arylation of Polyfluoroarenes with Organosilicon Reagents
  作者：Huixin Fan、Yaping Shang、Weiping Su

  DOI：10.1002/ejoc.201402091

  日期：2014.6

  The palladium-catalyzed direct arylation of polyfluoroarenes with organosilicon reagents was achieved by establishing general reaction conditions. This protocol was compatible with a broad range of functional groups and offered the desired products in moderate to good yields.

  通过建立一般反应条件，实现了钯催化的多氟芳烃与有机硅试剂的直接芳基化反应。该协议与广泛的官能团兼容，并以中等至良好的产量提供所需的产品。
• Pd-Catalyzed Direct Arylation of Polyfluoroarenes on Water under Mild Conditions Using PPh₃ Ligand
  作者：Fei Chen、Qiao-Qiao Min、Xingang Zhang

  DOI：10.1021/jo300036d

  日期：2012.3.16

  We report a Pd-catalyzed direct arylation of polyfluoroarenes with aryl iodides. The advantages of this reaction are its high reaction efficiency, excellent functional group compatibility, mild reaction conditions (70 degrees C), inexpensive PPh3 ligand, and use of pure water as reaction medium. The usefulness of this reaction has also been demonstrated by rapid preparation of highly functionalized polyfluoroarenes via iterative Pd-catalyzed C-H bond functionalization.
• Pd-catalysed decarboxylative Suzuki reactions and orthogonal Cu-based O-arylation of aromatic carboxylic acids
  作者：Jian-Jun Dai、Jing-Hui Liu、Dong-Fen Luo、Lei Liu

  DOI：10.1039/c0cc04104a

  日期：——

  Pd-catalysed decarboxylative Suzuki reactions and orthogonal Cu-based O-arylation reactions of aromatic carboxylic acids are reported. The new reactions may provide alternative routes for the synthesis of some biaryls and aromatic carboxylic esters.

  钯催化的脱羧Suzuki反应和芳香族羧酸的正交Cu基O-芳基化反应已有报道。新的反应可能为某些联芳基和芳族羧酸酯的合成提供替代途径。