8-(cyclohexyloxy)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 8-(cyclohexyloxy)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole
• 英文别名: 12-cyclohexyloxy-1,4-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-9(16),10(15),11,13-tetraene
• 化学式: C₂₀H₂₆N₂O
• 分子量: 310.4
• InChiKey: UNOCVRGWLFGNQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  26.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• MOBILIZATION OF HEMATOPOIETIC STEM CELLS
  申请人：Zheng Yi

  公开号：US20110020274A1

  公开（公告）日：2011-01-27

  Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and/or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.
• REJUVENATION OF PRECURSOR CELLS
  申请人：Children's Hospital Medical Center

  公开号：US20150297563A1

  公开（公告）日：2015-10-22

  The present invention relates generally to methods and pharmaceutical compositions for rejuvenating hematopoietic stem cells and progenitor cells from blood, intestinal tissue and dermal tissue by administration of at least one inhibitor of a GT-Pase, such as Cdc42 GTPase.
• US9433663B2
  申请人：——

  公开号：US9433663B2

  公开（公告）日：2016-09-06
• US9980942B2
  申请人：——

  公开号：US9980942B2

  公开（公告）日：2018-05-29
• [EN] MOBILIZATION OF HEMATOPOIETIC STEM CELLS<br/>[FR] MOBILISATION DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES
  申请人：CHILDRENS HOSP MEDICAL CENTER

  公开号：WO2009114725A2

  公开（公告）日：2009-09-17

  Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and/or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.