1,3-di-n-butoxy-2-methoxypropane | 1234705-06-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1,3-di-n-butoxy-2-methoxypropane
• 英文别名: 1-(3-Butoxy-2-methoxypropoxy)butane；1-(3-butoxy-2-methoxypropoxy)butane
• CAS: 1234705-06-6
• 化学式: C₁₂H₂₆O₃
• 分子量: 218.337
• InChiKey: CYUWJPLJVNYSJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  双布普醇 、 碘甲烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 1,3-di-n-butoxy-2-methoxypropane
  参考文献：
  名称：

  Ecotoxicity studies of glycerol ethers in Vibrio fischeri: checking the environmental impact of glycerol-derived solvents

  摘要：

  大多数由甘油衍生的醚类化合物对生物标志物弧菌菲氏弧菌的生态毒性低或无，这证明了这种基于生物的溶剂家族对环境的影响较小。

  DOI：

  10.1039/c5gc00857c
• 作为试剂：
  描述：

  D-GlcNAc 、 4-硝基苯基-D-吡喃葡糖苷 在 1,3-di-n-butoxy-2-methoxypropane 、 Thermus thermophilus β-galactosidase 作用下， 以 aq. phosphate buffer 为溶剂， 反应 3.0h， 以94%的产率得到N-acetyl-D-lactosamine
  参考文献：
  名称：

  Optimised N-acetyl-d-lactosamine synthesis using Thermus thermophilus β-galactosidase in bio-solvents

  摘要：

  Synthesis of N-acetyl-D-lactosamine (Gal-beta[1 -> 4]GlcNAc, LacNAc) catalyzed by beta-galactosidase from Thermus thermophilus (TTP0042) is affected by side reactions that give as result very low yields (about 20%) of LAcNAc when the reaction is performed in buffer. The process is improved (up to 91% of disaccharide yield) when the reaction takes place in the presence of solvents from biomass (bio-solvents) at 2.0 M concentration. Most of the solvents tested increased the LacNAc synthesis and reduced the undesired side reactions. In order to understand the possible effects of these solvents over the enzyme regioselectivity, we developed a conformational study of the enzyme structure in the presence of a selected bio-solvent by circular dichroism and fluorescence. According to this study, we were able to conclude that the presence of bio-solvents in the reaction media modifies the enzyme secondary and tertiary structure and this may be the cause of the regioselectivity changes observed in the trans-glycosylation reaction. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.11.053

文献信息

• BENZOXAZOLE DERIVATIVES
  申请人：Tohoku University

  公开号：EP2103611A1

  公开（公告）日：2009-09-23

  It is intended to provide a benzoxazole derivative or a pharmaceutically acceptable salt or solvate thereof which is useful in the early diagnosis of a conformation disease; a composition or a kit containing the same for diagnosing a conformation disease; a medical composition for ttreating and/or preventing a conformation disease; and so on.

  本发明旨在提供一种苯并恶唑衍生物或其药学上可接受的盐或溶液，该衍生物或其药学上可接受的盐或溶液可用于构象疾病的早期诊断；一种含有该衍生物或其药学上可接受的盐或溶液的组合物或试剂盒，该组合物或试剂盒可用于构象疾病的诊断；一种用于治疗和/或预防构象疾病的医用组合物，等等。
• Ecotoxicity studies of glycerol ethers in Vibrio fischeri: checking the environmental impact of glycerol-derived solvents
  作者：J. I. García、E. Pires、L. Aldea、L. Lomba、E. Perales、B. Giner

  DOI：10.1039/c5gc00857c

  日期：——

  Most glycerol-derived ethers display low or null ecotoxicity againstVibrio fischeribiomarker, supporting the low environmental impact of this biobased solvent family.

  大多数由甘油衍生的醚类化合物对生物标志物弧菌菲氏弧菌的生态毒性低或无，这证明了这种基于生物的溶剂家族对环境的影响较小。