DC_8,9 phosphatidyl 2-(hydroxyethyl)-maleic acid | 144750-76-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DC_8,9 phosphatidyl 2-(hydroxyethyl)-maleic acid
• 英文别名: (E)-4-[2-[2,3-di(tricosa-10,12-diynoyloxy)propoxy-hydroxyphosphoryl]oxyethoxy]-4-oxobut-2-enoic acid
• CAS: 144750-76-5
• 化学式: C₅₅H₈₇O₁₂P
• 分子量: 971.262
• InChiKey: ITRSEOMJQCVCQJ-XVIFHXHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17
• 重原子数：
  68
• 可旋转键数：
  49
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  172
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  1,2 bis (tricosa 10,12 diynoyl)-sn-3-glycerophosphocholine, DC_8,9PC 在 吡啶 、 acetate buffer 作用下， 以 异丙醇 为溶剂， 反应 10.0h， 生成 DC_8,9 phosphatidyl 2-(hydroxyethyl)-maleic acid
  参考文献：
  名称：

  Phosphatidylhydroxyalkanols as Versatile Intermediates in the Synthesis of Headgroup Modified Diacetylenic Phospholipids

  摘要：

  Phospholipase D extract (from savoy cabbage) mediates exchange of omega hydroxyalkanols (n= 2-4) with the choline moiety of phosphatidylcholines to produce corresponding phosphatidylhydroxyalkanols in >70% yield. The phosphatidyl hydroxyalkanol and its chloro analogue-were further reacted with molecules containing carboxylic and amine functionality respectively, providing an easy and efficient method to produce headgroup modified phospholipids.

  DOI：

  10.1080/00397919208019084

文献信息

• Phosphatidylhydroxyalkanols as Versatile Intermediates in the Synthesis of Headgroup Modified Diacetylenic Phospholipids
  作者：Alok Singh、Michael Markowitz、Li-I Tsao

  DOI：10.1080/00397919208019084

  日期：1992.8

  Phospholipase D extract (from savoy cabbage) mediates exchange of omega hydroxyalkanols (n= 2-4) with the choline moiety of phosphatidylcholines to produce corresponding phosphatidylhydroxyalkanols in >70% yield. The phosphatidyl hydroxyalkanol and its chloro analogue-were further reacted with molecules containing carboxylic and amine functionality respectively, providing an easy and efficient method to produce headgroup modified phospholipids.