1,2 bis (tricosa 10,12 diynoyl)-sn-3-glycerophosphocholine, DC_8,9PC | 75898-24-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1,2 bis (tricosa 10,12 diynoyl)-sn-3-glycerophosphocholine, DC_8,9PC
• 英文别名: 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine；1,2-bis(tricosa-10,12-diynoyl)-sn-3-phosphocholine；1,2 bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine；[(2R)-2,3-di(tricosa-10,12-diynoyloxy)propyl]2-(trimethylazaniumyl)ethylphosphate；2,3-di(tricosa-10,12-diynoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 75898-24-7
• 化学式: C₅₄H₉₂NO₈P
• 分子量: 914.3
• InChiKey: IDBJTPGHAMAEMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.3
• 重原子数：
  64
• 可旋转键数：
  46
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,2 bis (tricosa 10,12 diynoyl)-sn-3-glycerophosphocholine, DC_8,9PC 在 1-氯-N,N,2-三甲基丙烯胺 、 acetate buffer 作用下， 以 氯仿 、 异丙醇 为溶剂， 反应 10.0h， 生成 DC_8,9 phosphatidyl 2-chloroethanol
  参考文献：
  名称：

  Phosphatidylhydroxyalkanols as Versatile Intermediates in the Synthesis of Headgroup Modified Diacetylenic Phospholipids

  摘要：

  Phospholipase D extract (from savoy cabbage) mediates exchange of omega hydroxyalkanols (n= 2-4) with the choline moiety of phosphatidylcholines to produce corresponding phosphatidylhydroxyalkanols in >70% yield. The phosphatidyl hydroxyalkanol and its chloro analogue-were further reacted with molecules containing carboxylic and amine functionality respectively, providing an easy and efficient method to produce headgroup modified phospholipids.

  DOI：

  10.1080/00397919208019084

文献信息

• Bi-directionally crosslinked liposomes and method of making same
  申请人：Verily Life Sciences LLC

  公开号：US10842746B1

  公开（公告）日：2020-11-24

  Disclosed herein are methods for producing bi-directionally crosslinked liposomes. The methods include the steps of: providing a lipid composition comprising a plurality of reactive lipids, wherein each of the reactive lipids comprises a reactive hydrophobic group, a reactive hydrophilic group, or a reactive hydrophilic group and a reactive hydrophobic group; forming an un-crosslinked liposome comprising the reactive lipids; and crosslinking at least a portion of the reactive hydrophobic groups or the reactive hydrophilic groups; thereby producing the bi-directionally crosslinked liposomes. Bi-directionally crosslinked liposomes and methods for delivering therapeutic and/or diagnostic agents to subjects using the liposomes are also described.

  本文公开了生产双向交联脂质体的方法。这些方法包括以下步骤：提供包含多种活性脂质的脂质组合物，其中每种活性脂质包含一个活性疏水基团、一个活性亲水基团或一个活性亲水基团和一个活性疏水基团；形成包含活性脂质的未交联脂质体；交联至少一部分活性疏水基团或活性亲水基团；从而生产双向交联脂质体。此外，还描述了双向交联脂质体和使用该脂质体向受试者递送治疗和/或诊断制剂的方法。