ethyl 3,4,6-tri-O-benzoyl-2-deoxy-1-thio-β-D-glucopyranoside | 289902-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 3,4,6-tri-O-benzoyl-2-deoxy-1-thio-β-D-glucopyranoside
• 英文别名: [(2R,3S,4R,6S)-3,4-dibenzoyloxy-6-ethylsulfanyloxan-2-yl]methyl benzoate
• CAS: 289902-12-1
• 化学式: C₂₉H₂₈O₇S
• 分子量: 520.603
• InChiKey: VIOLAWCJHFWKAC-XPGKHFPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  113
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  ethyl 3,4,6-tri-O-benzoyl-2-deoxy-1-thio-β-D-glucopyranoside 在 palladium on activated charcoal 、 galactose-1-phosphate thymidylyltransferase sodium hydroxide 、 N-Iodosuccinamide 、 三氟甲磺酸 、 magnesium 、 氢气 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 uridine-5'-diphospho-2-deoxy-α-D-glucopyranose
  参考文献：
  名称：

  合成天然和“非天然”UDP-和 TDP-核苷酸糖的通用酶法

  摘要：

  DOI：

  10.1021/ja001444y
• 作为产物：
  描述：

  (乙基硫代)三甲基硅烷 、 在 zinc(II) iodide 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以48%的产率得到ethyl 3,4,6-tri-O-benzoyl-2-deoxy-1-thio-β-D-glucopyranoside
  参考文献：
  名称：

  合成天然和“非天然”UDP-和 TDP-核苷酸糖的通用酶法

  摘要：

  DOI：

  10.1021/ja001444y

文献信息

• Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and "unnatural" UDP- and TDP-nucleotide sugars
  申请人：——

  公开号：US20030055235A1

  公开（公告）日：2003-03-20

  The present invention provides mutant nucleotidylyl-transferases, such as E p , having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.

  本发明提供了一种突变型核苷酸转移酶，如E p ，具有改变的底物特异性；其生产方法；以及利用这些核苷酸转移酶生产核苷酸糖的方法。本发明还提供了使用天然和/或修饰的Ep或其他核苷酸转移酶合成所需的核苷酸糖的方法；以及通过本发明方法合成的核苷酸糖。本发明进一步提供了新的糖基磷酸酯，及其制造方法。
• ACTIVE-SITE ENGINEERING OF NUCLEOTIDYLYLTRANSFERASES AND GENERAL ENZYMATIC METHODS FOR THE SYNTHESIS OF NATURAL AND "UNNATURAL" UDP- AND TDP-NUCLEOTIDE SUGARS
  申请人：THORSON Jon

  公开号：US20070178487A1

  公开（公告）日：2007-08-02

  The present invention provides mutant nucleotidylyl-transferases, such as E p , having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified E p or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.

  本发明提供了突变核苷酸转移酶，例如Ep，具有改变的底物特异性；其生产方法；以及利用这些核苷酸转移酶生产核苷酸糖的方法。本发明还提供了使用天然和/或改性的Epor或其他核苷酸转移酶合成所需核苷酸糖的方法；以及通过本方法合成的核苷酸糖。本发明还提供了新的糖基磷酸酯，以及制备它们的方法。
• US7122359B2
  申请人：——

  公开号：US7122359B2

  公开（公告）日：2006-10-17
• US7906460B2
  申请人：——

  公开号：US7906460B2

  公开（公告）日：2011-03-15
• [EN] ACTIVE-SITE ENGINEERING OF NUCLEOTIDYLTRANSFERASES AND GENERAL ENZYMATIC METHODS FOR THE SYNTHESIS OF NATURAL AND "UNNATURAL" UDP-AND TDP-NUCLEOTIDE SUGARS<br/>[FR] TECHNIQUE DE SITE ACTIF DE NUCLEOTIDYLYL TRANSFERASES ET PROCEDES ENZYMATIQUES GENERAUX DE SYNTHESE DE SUCRES NUCLEOTIDES UDP ET TDP NATURELS ET ARTIFICIELS
  申请人：SLOAN KETTERING INST CANCER

  公开号：WO2002048331A2

  公开（公告）日：2002-06-20

  The present invention provides mutant nucleotidylyltransferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyltransferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide surgars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.