N-methylphenanthren-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: N-methylphenanthren-1-amine
• 化学式: C₁₅H₁₃N
• 分子量: 207.27
• InChiKey: CAKSMAIQMDFZTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Chromatographic materials for the separation of unsaturated molecules
  申请人：Waters Technologies Corporation

  公开号：US10092894B2

  公开（公告）日：2018-10-09

  The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.

  本公开涉及一种从混合物中分离相关化合物，特别是相关不饱和化合物的方法。使用色谱柱分离化合物，该色谱柱具有用于各种不同色谱模式的色谱固定相材料，其中含有第一取代基和第二取代基。在色谱条件下，第一取代基可最大程度地减少化合物保留时间的变化。第二取代基通过加入一个或多个芳香族、多芳香族、杂环芳香族或多杂环芳香族烃基团（每个基团可选择被脂肪族基团取代），在色谱上选择性地保留化合物。
• CHROMATOGRAPHIC MATERIALS FOR THE SEPARATION OF UNSATURATED MOLECULES
  申请人：Waters Technologies Corporation

  公开号：EP3113857A1

  公开（公告）日：2017-01-11
• [EN] CHROMOTOGRAPHIC MATERIALS FOR THE SEPARATION OF UNSATURATED MOLECULES<br/>[FR] MATÉRIAUX CHROMATOGRAPHIQUES POUR LA SÉPARATION DE MOLÉCULES INSATURÉES
  申请人：WATERS TECHNOLOGIES CORP

  公开号：WO2015134317A1

  公开（公告）日：2015-09-11

  The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.
• [EN] CHROMATOGRAPHIC MATERIALS FOR THE SEPARATION OF UNSATURATED MOLECULES<br/>[FR] MATÉRIAUX CHROMATOGRAPHIQUES POUR LA SÉPARATION DE MOLÉCULES INSATURÉES
  申请人：WATERS TECHNOLOGIES CORP

  公开号：WO2015134317A9

  公开（公告）日：2016-08-04

  [EN] The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.
  [FR] La présente invention concerne un procédé de séparation d'un composé d'intérêt, en particulier un ou plusieurs composés insaturés d'intérêt, à partir d'un mélange. Le composé est séparé à l'aide d'une colonne ayant un matériau de phase stationnaire de chromatographie adapté à divers modes différents de chromatographie contenant un premier substituant et un second substituant. Le premier substituant réduit à un minimum la variation de rétention du composé au cours du temps dans des conditions chromatographiques. Le second substituant retient de façon chromatographique et sélectivement le composé par incorporation d'un ou de plusieurs groupes aromatiques, polyaromatiques, hétérocycles aromatiques ou hydrocarbures aromatiques polyhétérocycliques, chaque groupe étant éventuellement substitué par un groupe aliphatique.
• [EN] COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF HYPERAMMONEMIA<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PRÉVENTION ET DE TRAITEMENT D'HYPERAMMONÉMIE
  申请人：CHILDRENS NAT MEDICAL CT

  公开号：WO2019071104A1

  公开（公告）日：2019-04-11

  The present disclosure is directed, in part, to compounds, or pharmaceutically acceptable compositions thereof, for treating and or preventing hyperammonemia. The present invention is also directed, in part, to methods of treating or preventing a hyperammonemia-associated disorder or symptom(s), in particular wherein the hyperammonemia-associated disorder or symptom(s) occurs in the brain of the subject.