1-Allyl-3-methoxycarbonyl-pyrrolidon-(5) | 71548-52-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Allyl-3-methoxycarbonyl-pyrrolidon-(5)
• 英文别名: 1-Allyl-4-methoxycarbonyl-pyrrolidin-2-on；Methyl N-allyl-5-oxo-3-pyrrolidinylcarboxylat；1-allyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester；1-Allyl-5-oxo-pyrrolidin-3-carbonsaeure-methylester；N-allyl-4-carbomethoxy pyrrolidone；methyl 5-oxo-1-prop-2-enylpyrrolidine-3-carboxylate
• CAS: 71548-52-2
• 化学式: C₉H₁₃NO₃
• 分子量: 183.207
• InChiKey: QFIHRBSYJXBJNX-UHFFFAOYSA-N

物化性质

• 沸点：
  120 °C(Press: 0.8 Torr)
• 密度：
  1.123±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Allyl-3-methoxycarbonyl-pyrrolidon-(5) 在 chloroplatinic acid 作用下， 以 异丙醇 为溶剂， 生成 N-[Bis(methyl ethylketoximino) methylsilylpropyl]-4-carbomethoxy pyrrolidone
  参考文献：
  名称：

  Silicone monomers and oligomers having a carboxyl functional group

  摘要：

  提供含有至少一个羧酸酯官能团的有机硅单体和有机硅氧烷单体，该官能团由以下式子表示：##STR1## 其中：R可以是相同或不同的水解基团；R.sup.1可以是被取代或未被取代的烷基、环烷基、被取代或未被取代的芳基、烯基、炔基或--OS.sub.i (R.sup.1).sub.3；x为0至3；R.sup.2为1-12碳原子的线性或支链烷基；B为--NR.sup.10，其中R.sup.10为氢或公式--CH.sub.2 --CH(COOR.sup.6)--CH.sub.2 COOR.sup.6的二羧酸酯基团；R.sup.5为氢或烷基；R.sup.6为烷基；F为1-10碳原子的线性或支链烷基；R.sup.3为##STR2##

  公开号：

  US06093829A1
• 作为产物：
  描述：

  衣康酸二甲酯 、 丙烯胺 在 甲醇 作用下， 生成 1-Allyl-3-methoxycarbonyl-pyrrolidon-(5)
  参考文献：
  名称：

  US2826588

  摘要：

  公开号：

文献信息

• [EN] PYRROLIDONE DERIVATIVES, OLIGOMERS AND POLYMERS<br/>[FR] DÉRIVÉS DE PYRROLIDONE, OLIGOMÈRES ET POLYMÈRES
  申请人：NANOSYNTHONS LLC

  公开号：WO2016040962A1

  公开（公告）日：2016-03-17

  Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGaylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described. These compounds have a variety of applications such as in cellular imaging, gene transfection, bio-diagnostics, biosensing, fluorescence directed surgical resections, drug delivery, forensics, environmental diagnostics, mineral/gemstone characterization, counterfeit goods detection, tracer studies related to liquid/water flow, oil field enhancements and diagnostics, prevention of photo-bleaching, and LED display enhancements and others.

  简单的有机结构、有机/无机聚合物和其他基质已经制备出来，所有这些基质都至少含有一个吡咯烷酮基团，并且发现它们具有低毒性、低补体激活特性，可以用作注射组成物，以减少蛋白质与药物结合物的相互作用，同时增强这些结合物在体内的驻留时间；因此，这些化合物可以用作PEG化的替代品。令人惊讶的是，这些化合物还表现出独特的内在荧光(IF)或非传统荧光(NTF)特性，目前无法用传统的光化学和荧光范式来解释。这些化合物具有各种应用，如细胞成像、基因转染、生物诊断、生物传感、荧光引导手术切除、药物传递、法医学、环境诊断、矿物/宝石表征、伪造商品检测、液体/水流追踪研究、油田增产和诊断、防止光漂白和LED显示增强等。
• Silicone monomers and oligomers having a carboxyl functional group thereon
  申请人：MONA INDUSTRIES, INC.

  公开号：EP1314736A2

  公开（公告）日：2003-05-28

  There is provided oganosiloxane compounds and oligomers containing at least one carboxylic ester functional group that may be represented by the formula: wherein: Ra, which can be the same or different are hydrolysable groups; R1a, which can be the same or different, are selected from substituted or unsubstituted alkyl, cycloalkyle, substituted or unsubstituted aryl, aralkyl, alkenyl, alkynyl or -O-Si(R4)3 groups or mixtures of the same; R7 and R8, which may be the same or different, are selected from alkyl, aryl, capped or uncapped polyoxyalkylene, alkaryl, aralkylene, alkenyl or alkynyl or mixtures of the same; M, which can be the same or different is selected from hydrogen, Ra, R1 or CH2-CHR6-R6-Bn1-Fn-R3 with the proviso that at least one M group is CH2-CHR6-R6-Bn1-Fn-R12; y is zero to 2; B is -NR6, sulfur or oxygen; R6 is hydrogen or alkyl; R2 is linear or branched alkylene of 1-12 carbon atoms; F is linear or branched alkylène of 1-10 carbon atoms; n1 is zero or 1; n is zero or 1, with the proviso that if n1 is 1, n is 1 and if n1 is 0, n is 0; R3 is R5 is alkyl or trialkylsilyl; a is from zero to 10; and b is from zero to 10.

  本发明提供了含有至少一个羧酸酯官能团的有机硅氧烷化合物和低聚物，可由式表示： 其中 Ra（可以相同或不同）为可水解基团； R1a，可以相同或不同，选自取代或未取代的烷基、环烷基、取代或未取代的芳基、芳烷基、烯基、炔基或-O-Si(R4)3 基团或它们的混合物； R7 和 R8（可以相同或不同）选自烷基、芳基、有封端的或无封端的聚氧亚烷基、烷芳基、芳烷基、烯基或炔基或它们的混合物； M（可以相同或不同）选自氢、Ra、R1 或 CH2-CHR6-R6-Bn1-Fn-R3，但至少有一个 M 基团为 CH2-CHR6-R6-Bn1-Fn-R12 y 为 0 至 2； B是-NR6、硫或氧； R6 是氢或烷基 R2 是 1-12 个碳原子的直链或支链亚烷基； F 是 1-10 个碳原子的直链或支链烯烃； n1 为零或 1； n 为 0 或 1，但如果 n1 为 1，则 n 为 1，如果 n1 为 0，则 n 为 0； R3 是 R5 是烷基或三烷基硅烷基； a 为 0 至 10；以及 b 为 0 至 10。
• Organopolysiloxane compound and amidoamine compound, and cosmetic preparation
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2289975A2

  公开（公告）日：2011-03-02

  An organopolysiloxane compound having a weight average molecular weight of 300 to 200,000 and having in one molecule at least one organic group represented by the following formula (1) and at least one selected from (SiO2) unit and (R1SiO3/2) unit, wherein R2 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkali metal, A independently represents an alkylene group, B represents -NR3-, sulfur or oxygen atom, n is 0 or 2, n1 is 0 or 1, and n2 is 0 or 1 provided that when n is 0 and n2 is 1, n1 is 1, when n is 2 and n2 is 1, n1 is 0 or 1, and when n is 2 and n2 is 0, n1 is 0.

  一种有机聚硅氧烷化合物，其重量平均分子量在 300 至 200,000 之间，在一个分子中至少有一个由下式（1）代表的有机基团和至少一个选自（SiO2）单元和（R1SiO3/2）单元、 其中 R2 代表氢原子、具有 1 至 6 个碳原子的烷基或碱金属，A 独立地代表亚烷基，B 代表-NR3-、硫或氧原子，n 为 0 或 2，n1 为 0 或 1，n2 为 0 或 1，条件是当 n 为 0 且 n2 为 1 时，n1 为 1，当 n 为 2 且 n2 为 1 时，n1 为 0 或 1，当 n 为 2 且 n2 为 0 时，n1 为 0。
• Pyrrolidone derivatives, oligomers and polymers
  申请人：NanoSynthons LLC

  公开号：US10420849B2

  公开（公告）日：2019-09-24

  Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGaylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described. These compounds have a variety of applications such as in cellular imaging, gene transfection, bio-diagnostics, biosensing, fluorescence directed surgical resections, drug delivery, forensics, environmental diagnostics, mineral/gemstone characterization, counterfeit goods detection, tracer studies related to liquid/water flow, oil field enhancements and diagnostics, prevention of photo-bleaching, and LED display enhancements and others.

  我们已经制备出了简单的有机结构、有机/无机聚合物和其他基质，所有这些基质都至少含有一个吡咯烷酮分子，并发现它们具有低毒性、低补体激活特性，可用于减少蛋白质与药物共轭物的相互作用，同时在用作注射组合物时可提高这些共轭物在体内的驻留时间；因此，这些化合物可用作 PEGaylation 中 PEG 的替代品。令人惊奇的是，这些化合物还表现出独特的本征荧光（IF）或非传统荧光（NTF）特性，而这些特性目前无法用传统的光化学和荧光范式来解释。这些化合物有多种应用，如细胞成像、基因转染、生物诊断、生物传感、荧光引导手术切除、给药、法医、环境诊断、矿物/宝石表征、假冒商品检测、与液体/水流有关的示踪研究、油田增强和诊断、防止光漂白、LED 显示屏增强等。
• EP0951468A4
  申请人：——

  公开号：EP0951468A4

  公开（公告）日：2001-06-06