苄菊酯 | 70-38-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 苄菊酯
• 中文别名: 菊酯-2,4-二甲基苯甲基酯
• 英文名称: Dimethrin
• 英文别名: (2,4-dimethylphenyl)methyl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate
• CAS: 70-38-2
• 化学式: C₁₉H₂₆O₂
• 分子量: 286.4
• InChiKey: FHNKBSDJERHDHZ-UHFFFAOYSA-N

物化性质

• 熔点：
  <25 °C
• 沸点：
  175 °C(Press: 3.8 Torr)
• 密度：
  0.986 g/cm3
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）
• 颜色/状态：
  Amber liquid

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

代谢

... 二甲基恶虫灵（5毫克/千克），通过插管给予兔，被代谢（通过还原）并以菊花酸和2,4-二甲基苯甲酸葡萄糖苷酸酯的形式从尿液中排出。

... Dimethrin (5 mg/kg), administered by intubation to rabbits, is metabolized (by reduction) and excreted in the urine as chrysanthemumic acid and the glucuronic ester of 2,4-dimethyl benzoic acid.

来源:Hazardous Substances Data Bank (HSDB)

代谢

拟除虫菊酯类化合物对哺乳动物的毒性较低，这主要是由于它们通过酯水解和/或羟基化被迅速生物转化的结果。

The low toxicity of pyrethroids in mammals is due largely to their rapid biotransformation by ester hydrolysis and/or hydroxylation. /Pyrethroids/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

神经毒素 - 其他中枢神经系统神经毒素

Neurotoxin - Other CNS neurotoxin

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

添加剂（例如石油馏分），如果存在，对患者造成的毒性威胁大于活性成分本身。 ... 当存在石油馏分添加剂时，不应诱导呕吐。 ... 对于意识清醒、咽反射正常且摄入了亚致死量除虫菊酯且没有其他有毒成分的人，可以通过使用吐根糖浆诱导呕吐，随后使用盐水泻药和活性炭悬浮液。 ... 肺部和过敏后遗症对症治疗，包括维持呼吸道通畅、吸氧和必要时提供呼吸支持。可以使用标准药物和管理方案来治疗支气管痉挛和过敏性休克。癫痫发作使用地西泮治疗。 /除虫菊酯和合成拟除虫菊酯/

The additives (e.g. petroleum distillate), when present, represent a greater toxic threat to the patient than the active ingredient itself. ... Emesis should not be induced when petroleum distillate additives are present. ... The alert person with an intact gag reflex & a sublethal pyrethrum ingestion without other toxic constituents may have emesis induced by ipecac, followed by a saline cathartic & slurry of activated charcoal. ... Pulmonary & allergic sequelae are treated symptomatically with airway maintenance, oxygen, & ventilatory assistance as required. Standard drugs and management protocols may be used for treatment of bronchospasm & anaphylaxis. Seizures are treated with diazepam. /Pyrethrum and synthetic pyrethroids/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。预测并处理癫痫发作，如有必要...。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛...。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。给予活性炭...。/拟除虫菊酯、拟除虫菊酯类和相关化合物/

Basic treatment: . Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Anticipate seizures and treat if necessary... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Pyrethrins, pyrethroids, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于无意识的病人，考虑进行口对口或鼻对鼻气管插管以控制气道。监测心率和必要时治疗心律失常...。开始静脉输液，使用D5W/SRP：“保持开放”，最低流速...。如果出现低血容量的迹象，使用乳酸钠林格氏液。注意液体过载的迹象...。用安定（安定）治疗癫痫...。使用丙美卡因氢氯化物协助眼睛冲洗...。/除虫菊酯、拟除虫菊酯和有关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for air way control in the patient who is unconscious. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Pyrethrins, pyrethroids, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

皮肤去污。立即用肥皂和水清洗皮肤……。如果出现刺激或感觉异常效果，请由医生进行治疗。由于拟除虫菊酯的挥发显然是导致面部感觉异常的原因，应采取强烈措施（通风、保护面罩和头罩）以避免蒸汽接触面部和眼睛。维生素E油制剂（dL-α-生育酚醋酸酯）在预防和停止感觉异常反应方面具有独特效果。它们在野外条件下应用于皮肤是安全的。玉米油也有一定效果，但可能的副作用使得长期使用不太合适。凡士林的效果不如玉米油。氧化锌实际上会加剧反应。/拟除虫菊酯/

Skin decontamination. Wash skin promptly with soap and water ... . If irritant or paresthetic effects occur, obtain treatment by a physician. Because volatilization of pyrethroids apparently accounts for paresthesia affecting the face, strenuous measures should be taken (ventilation, protective face mask and hood) to avoid vapor contact with the face and eyes. Vitamin E oil preparations (dL-alpha tocopheryl acetate) are uniquely effective in preventing and stopping the paresthetic reaction. They are safe for application to the skin under field conditions. Corn oil is somewhat effective, but possible side effects with continuing use make it less suitable. Vaseline is less effective than corn oil. Zinc oxide actually worsens the reaction. /Pyrethroids/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

四只兔子通过插管给予了每千克5毫升的未稀释的二甲基菊酯。在72小时内，每隔24小时收集一次尿液。尿液中两种可能代谢物的鉴定表明二甲基菊酯已被吸收。

... Four rabbits were given 5 ml/kg of undiluted dimethrin by intubation. Urine was collected every 24 hr over a 72 hr period. Identification of two possible metabolites in the urine indicated that dimethrin was absorbed.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  9
• 包装等级：
  III

制备方法与用途

类别：农药

毒性分级：低毒

急性毒性：

• 大鼠口服 LD50: 40,000 毫克/公斤
• 小鼠口服 LD50: 10,000 毫克/公斤

储运特性：

• 库房应通风、低温和干燥
• 储运时需与食品原料分开

灭火剂：干粉、泡沫、砂土

文献信息

• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• Thieno-pyrimidine compounds having fungicidal activity
  申请人：Brewster Kirkland William

  公开号：US20070093498A1

  公开（公告）日：2007-04-26

  The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

  本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• Novel insecticides
  申请人：Syngenta Participations AG

  公开号：EP2540718A1

  公开（公告）日：2013-01-02

  Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared in a manner known per se.

  式I的化合物 其中取代基如权利要求1所定义，并且式I化合物的农药可接受盐以及所有立体异构体和互变异构形式可用作杀虫剂，并且可以按照已知的方法制备。
• Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
  申请人：Dow AgroSciences LLC

  公开号：US20180279612A1

  公开（公告）日：2018-10-04

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产此类分子的过程，用于此类过程的中间体，含有此类分子的杀虫组合物，以及使用此类杀虫组合物对抗此类害虫的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。