Free radical reactions for heterocycle synthesis. Part 6: 2-Bromobenzoic acids as building blocks in the construction of nitrogen heterocycles
作者:Wei Zhang、Georgia Pugh
DOI:10.1016/s0040-4020(03)00381-8
日期:2003.4
A general method to construct a variety of nitrogen heterocycles is introduced. 2-Bromobenzoic acids or acid chlorides are used as the common building blocks to couple with appropriate nitrogen-containing compounds. Sequential aryl radical cyclizations including conjugate additions, spirocyclizations, homolytic and ipso aromatic substitutions, and 1,5-hydrogen atom transfers are employed to prepare