6-甲基吡啶-2-羧酸盐酸盐 | 87884-49-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 6-甲基吡啶-2-羧酸盐酸盐
• 英文名称: 6-methylpyridine-2-carboxylic acid hydrochlorid salt
• 英文别名: 6-methyl-pyridine-2-carboxylic acid ; hydrochloride；6-Methyl-pyridin-2-carbonsaeure; Hydrochlorid；6-Methyl-picolinsaeure-hydrochlorid；6-Methylpicolinic acid hydrochloride；6-methylpyridine-2-carboxylic acid;hydrochloride
• CAS: 87884-49-9
• 化学式: C₇H₇NO₂*ClH
• 分子量: 173.599
• InChiKey: TUQJTJPDQVKNSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.51
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  50.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-甲基吡啶-2-羧酸盐酸盐 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 、 水 为溶剂， 60.0 ℃ 、413.68 kPa 条件下， 反应 24.0h， 以87%的产率得到cis-6-methylpipecolinic acid
  参考文献：
  名称：

  An improved synthesis of homoproline and derivatives

  摘要：

  DOI：

  10.1021/jo00289a058
• 作为产物：
  描述：

  2-甲基吡啶氧化物 在 盐酸 、 二甲氨基甲酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 生成 6-甲基吡啶-2-羧酸盐酸盐
  参考文献：
  名称：

  An improved synthesis of homoproline and derivatives

  摘要：

  DOI：

  10.1021/jo00289a058

文献信息

• [EN] HETARYL-[1,8]NAPHTHYRIDINE DERIVATIVES<br/>[FR] DÉRIVÉS D'HÉTARYL-[1,8]NAPHTYRIDINE
  申请人：MERCK PATENT GMBH

  公开号：WO2011095196A1

  公开（公告）日：2011-08-11

  Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) wherein R1, R2, W1, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.

  新型杂环-[1,8]萘啶衍生物的化学式（I），其中R1、R2、W1、W3、W5和W6的含义如权利要求书中所述，是ATP消耗蛋白的抑制剂，可用于治疗肿瘤。
• Hetaryl-[1,8]naphthyridine derivatives
  申请人：Jonczyk Alfred

  公开号：US20120295902A1

  公开（公告）日：2012-11-22

  Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) wherein R1, R2, W 1 , W 3 , W 5 and W 6 have the meaning according to claim 1 , are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.

  新型杂芳基-[1,8]萘啶衍生物的化学式（I），其中R1、R2、W1、W3、W5和W6的含义如权利要求书中所述，是ATP消耗蛋白的抑制剂，可用于治疗肿瘤。
• HETARYLAMINONAPHTHYRIDINES
  申请人：Jonczyk Alfred

  公开号：US20120316166A1

  公开（公告）日：2012-12-13

  Novel hetarylaminonaphthyridine derivatives of formula (I) wherein X, R1, R2, R3, R4, W1, W2, W3, W5 and W6 have the meaning according to claim 1 , are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.

  新型hetarylaminonaphthyridine衍生物的化学式(I)，其中X、R1、R2、R3、R4、W1、W2、W3、W5和W6的含义根据权利要求，是ATP消耗蛋白的抑制剂，可用于治疗肿瘤等。
• P2X4 receptor antagonist
  申请人：NIPPON CHEMIPHAR CO., LTD

  公开号：US10633349B2

  公开（公告）日：2020-04-28

  The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(═O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(═O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(═O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof, and a P2X4 receptor antagonist.

  本发明涉及一种由以下通式(I)代表的二氮卓衍生物(式中，R1和R2代表氢原子等，或R1和R2结合在一起与它们结合的苯环一起形成萘环等，R3和R4代表氢原子等，R5代表氢原子等，R6和R7代表氢原子等，X代表C、CH或N，Y代表N、NH或C(═O)、Z 代表氧原子或硫原子，A 代表苯环等，B 代表 NHC(═O) 等，D 代表原子键等、或其药理学上可接受的盐，以及 P2X4 受体拮抗剂。
• Antiallergic agents. 3. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides
  作者：Yasushi Honma、Kyoji Hanamoto、Tomiki Hashiyama、Yasuo Sekine、Mikio Takeda、Yasutoshi Ono、Kei Tsuzurahara

  DOI：10.1021/jm00368a005

  日期：1984.2

  A series of N-tetrazolylpyridinecarboxamides was prepared and evaluated for antiallergic activity by the passive cutaneous anaphylaxis (PCA) assay. From the structure-activity relationships (SAR) of this class of compounds, it was revealed that the N-tetrazolylcarbamoyl group as an acidic functionality is required to be at the 2-position of the pyridine nucleus and that the phenyl group as a subtituent is not necessarily required for activity. 6-Methyl-N-(1H-tetrazol-5-yl)-2-pyridinecarboxamide (36) showed good oral activity and low toxicity.