4-Isopropyl-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Isopropyl-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
• 英文别名: Ethyl 5-oxo-4-propan-2-ylpyrrolidine-2-carboxylate
• 化学式: C₁₀H₁₇NO₃
• mdl: MFCD07776247
• 分子量: 199.25
• InChiKey: QKWOBDAUJPYMLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Ethyl 2-isocyano-5-methylhex-4-enoate 、 2-巯基乙醇 在 2-氨基-3-氯-1,4-萘醌 作用下， 以 甲苯 为溶剂， 反应 0.08h， 生成 4-Isopropyl-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols

  摘要：

  Alkenyl and alkynyl isocyanides were synthesised and then reacted, using microwave flash-heating technology, with thiophenol, 2-mercaptoethanol and ethanethiol, in the presence of a radical initiator, to give highly functionalised pyrrolines and pyroglutamates. Direct comparison with results obtained using traditional heating techniques showed the advantage of using the microwave technology in terms of faster reactions and better yields. (C) 2003 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)02888-5

文献信息

• PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS
  申请人：Philippe Michel

  公开号：US20100028280A1

  公开（公告）日：2010-02-04

  The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

  该发明涉及一种直发角蛋白纤维的拉直过程，包括：(i)将至少两种变性剂含有的拉直组合物涂抹到角蛋白纤维上的步骤，(ii)使用加热装置将角蛋白纤维的温度升高至110至250°C的步骤。
• Method for straightening keratinous fibres using heating means and an amide
  申请人：Malle Gérard

  公开号：US10092490B2

  公开（公告）日：2018-10-09

  The invention concerns a method for straightening keratinous fibers including: (i) a step of applying on the keratinous fibers a hair straightening composition containing at least one cyclic or linear amide, (ii) a step of increasing the temperature of the keratinous fibers, using heating means, to a temperature ranging between 110 and 250° C.

  本发明涉及一种拉直角质纤维的方法，包括：(i) 在角质纤维上涂抹含有至少一种环状或线性酰胺的拉直头发组合物，(ii) 使用加热装置将角质纤维的温度升高到 110 至 250 摄氏度之间。
• METHOD FOR STRAIGHTENING KERATINOUS FIBRES USING HEATING MEANS AND AN AMIDE
  申请人：Malle Gérard

  公开号：US20100163070A1

  公开（公告）日：2010-07-01

  The invention concerns a method for straightening keratinous fibers including: (i) a step of applying on the keratinous fibers a hair straightening composition containing at least one cyclic or linear amide, (ii) a step of increasing the temperature of the keratinous fibers, using heating means, to a temperature ranging between 110 and 250° C.
• US8765107B2
  申请人：——

  公开号：US8765107B2

  公开（公告）日：2014-07-01