N,N'-dioctanoylhydrazine | 1530-75-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-dioctanoylhydrazine
• 英文别名: N,N'-Dioctanoyl-hydrazin；Caprylsaeuresym-dihydrazid；Dioctanoyl-hydrazin；1,2-di-n-octanoylhydrazine；N'-octanoyloctanehydrazide
• CAS: 1530-75-2
• 化学式: C₁₆H₃₂N₂O₂
• 分子量: 284.442
• InChiKey: KNYNXZMMGGMPJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  octanoic acid hydrazide; hydrochloride 在 乙醇 、 canamide 作用下， 生成 N,N'-dioctanoylhydrazine
  参考文献：
  名称：

  Takase, Nippon Kagaku Zasshi, 1958, vol. 79, p. 1500,1502

  摘要：

  DOI：

文献信息

• Lipase-Catalyzed Synthesis of Carboxylic Amides: Nitrogen Nucleophiles as Acyl Acceptor
  作者：Fred van Rantwijk、Michiel A. P. J. Hacking、Roger A. Sheldon

  DOI：10.1007/s007060070086

  日期：2000.6.15

   The lipase-catalyzed aminolysis of carboxylic esters is a fairly general reaction that has been performed with a wide range of esters and amines, generally in anhydrous organic media to avoid undesirable hydrolysis of the ester. Alternatively, carboxylic amides can be synthesized by lipase mediated condensation of carboxylic acids and amines if an excess of either reactant is avoided.

   脂肪酶催化的羧酸酯的氨解反应是相当普遍的反应，通常在无水有机介质中用多种酯和胺进行，以避免酯发生不希望的水解。或者，如果避免了任何一种反应物的过量，则可以通过脂肪酶介导的羧酸和胺的缩合来合成羧酸酰胺。
• Process for the preparation of symmetrical diacylhydrazines
  申请人：Great Lakes Chemical (Europe) GmbH

  公开号：US06444848B1

  公开（公告）日：2002-09-03

  Process for the preparation of symmetrical diacylhydrazines having general formula (I): R1—CO—NH—NH—CO—R1 wherein R1 represents a linear or branched C1-C18 alkyl group; a linear or branched C2-C8 alkoxyalkyl group; a C2-C8 cyanoalkyl group; a C5-C8 cycloalkyl group, said cycloalkyl group optionally containing a heteroatom selected from oxygen, nitrogen and sulfur; a C6-C18 aryl group; a C7C20 arylalkyl group or alkylaryl group, said arylalkyl or alkylaryl groups optionally substituted with one or more hydroxyl groups, or with one or more linear or branched C1-C8 alkoxyl groups; comprising: (a) reacting an ester of a carboxylic acid having general formula (II): R1—CO—OR2 wherein R1 has the same meanings defined above and R2 represents a linear or branched C1-C18 alkyl group, with hydrazine, in its pure or hydrated state, obtaining a monoacylhydrazine having general formula (III): R1—CO—NH—NH2; (b) reacting the monoacylhydrazine having general formula (III) obtained in step (a), with a &bgr;-ketoester having general formula (IV): R3—CO—CH2—COOR4 wherein R3 represents a linear or branched C1-C18 alkyl group, or a C6-C18 aryl group and R4 represents a linear or branched C1-C18 alkyl group, obtaining the desired symmetrical diacylhydrazine having general formula (I).

  制备具有通式(I)的对称二酰肼的过程如下：其中R1代表线性或支链C1-C18烷基；线性或支链C2-C8烷氧基烷基；C2-C8氰基烷基；C5-C8环烷基，所述环烷基可以选择氧、氮和硫作为杂原子；C6-C18芳基；C7-C20芳基烷基或烷基芳基，所述芳基烷基或烷基芳基可以选择一个或多个羟基或一个或多个线性或支链C1-C8烷氧基进行取代；包括以下步骤：(a)将具有通式(II)的羧酸酯与纯态或水合态的肼反应，得到具有通式(III)的单酰肼：R1—CO—NH—NH2；(b)将步骤(a)中获得的具有通式(III)的单酰肼与具有通式(IV)的β-酮酯反应：R3—CO—CH2—COOR4，其中R3代表线性或支链C1-C18烷基或C6-C18芳基，R4代表线性或支链C1-C18烷基，得到所需的具有通式(I)的对称二酰肼。
• PROCESS FOR THE PREPARATION OF SYMMETRICAL DIACYLHYDRAZINES
  申请人：Great Lakes Chemical (Europe) GmbH

  公开号：EP1135363A1

  公开（公告）日：2001-09-26
• US6444848B1
  申请人：——

  公开号：US6444848B1

  公开（公告）日：2002-09-03
• [EN] PROCESS FOR THE PREPARATION OF SYMMETRICAL DIACYLHYDRAZINES<br/>[FR] PROCEDE DE PREPARATION DE DIACYLHYDRAZINES SYMETRIQUES
  申请人：GREAT LAKES CHEMICAL EUROP

  公开号：WO2000034227A1

  公开（公告）日：2000-06-15

  Process for the preparation of symmetrical diacylhydrazines having general formula (I): R1-CO-NH-NH-CO-R1 wherein R1 represents a linear or branched C1-C18 alkyl group; a linear or branched C2-C8 alkoxyalkyl group; a C2-C8 cyanoalkyl group; a C5-C8 cycloalkyl group, said cycloalkyl group optionally containing a heteroatom selected from oxygen, nitrogen and sulfur; a C6-C18 aryl group; a C7-C20 arylalkyl group or alkylaryl group, said arylalkyl or alkylaryl groups optionally substituted with one or more hydroxyl groups, or with one or more linear or branched C1-C8 alkoxyl groups; comprising: (a) reacting an ester of a carboxylic acid having general formula (II): R1-CO-OR2 wherein R1 has the same meanings defined above and R2 represents a linear or branched C1-C18 alkyl group, with hydrazine, in its pure or hydrated state, obtaining a monoacylhydrazine having general formula (III): R1-CO-NH-NH2; (b) reacting the monoacylhydrazine having general formula (III) obtained in step (a), with a β-ketoester having general formula (IV): R3-CO-CH2-COOR4 wherein R3 represents a linear or branched C1-C18 alkyl group, or a C6-C18 aryl group and R4 represents a linear or branched C1-C18 alkyl group, obtaining the desired symmetrical diacylhydrazine having general formula (I).