3-(o-Tolyloxy)sulfolan | 53583-32-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(o-Tolyloxy)sulfolan
• 英文别名: Thiophene, tetrahydro-3-(methylphenoxy)-, 1,1-dioxide；3-(2-methylphenoxy)thiolane 1,1-dioxide
• CAS: 53583-32-7
• 化学式: C₁₁H₁₄O₃S
• mdl: MFCD00449146
• 分子量: 226.296
• InChiKey: KPSIRPMVAVWAIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• INHIBITORS OF ERK NUCLEAR TRANSLOCATION
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US20210292338A1

  公开（公告）日：2021-09-23

  Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R 1 and R′ 1 are aryl or heteroaryl as defined herein; and R 2 and R′ 2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.
• [EN] INHIBITORS OF ERK NUCLEAR TRANSLOCATION<br/>[FR] INHIBITEURS DE LA TRANSLOCATION NUCLÉAIRE D'ERK
  申请人：YEDA RES & DEV

  公开号：WO2020115744A1

  公开（公告）日：2020-06-11

  Described herein are compounds having Formula (I) or Formula (II): wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R'1 are aryl or heteroaryl as defined herein; and R 2 and R' 2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula (I) or Formula (II). The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.