6-甲氧基辛可宁脲盐酸盐 | 116104-94-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 中文名称: 6-甲氧基辛可宁脲盐酸盐
• 中文别名: 尿素金雞納鹼鹽酸鹽
• 英文名称: Quinine urea hydrochloride
• 英文别名: (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;urea;hydrochloride
• CAS: 116104-94-0；908573-75-1；549-52-0
• 化学式: C21H29ClN4O3
• 分子量: 420.9
• InChiKey: VSBIHZIPRXLKFY-HZQSTTLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.62
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 危险等级：
  6.1(b)

文献信息

• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Compositions and methods to effect the release profile in the transdermal administration of active agents
  申请人：——

  公开号：US20020004065A1

  公开（公告）日：2002-01-10

  Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

  本发明涉及一种用于经皮递送活性药剂的组合物和方法，该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂，包括一种药学上可接受的粘合基质和一种聚合物塑料材料，该聚合物塑料材料对活性药剂具有释放速率调节作用。
• Transdermal drug delivery device including an occlusive backing
  申请人：Noven Pharmaceuticals, Inc.

  公开号：US10231938B2

  公开（公告）日：2019-03-19

  A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer.

  一种透皮给药系统，用于局部应用一种或多种活性剂，这些活性剂包含在一个或多个聚合物和/或粘合剂载体层中，靠近一个不含药物的聚合物背层，该背层可通过调节聚合物背层的湿气透过率来控制透皮给药系统的给药速率和概况。
• Technology for preparation of macromolecular microspheres
  申请人：Ansun Biopharma, Inc.

  公开号：US10583086B2

  公开（公告）日：2020-03-10

  Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.

  微球是通过将蛋白质或其他大分子的水溶液与有机溶剂和反离子接触，然后将溶液冷却而制成的。微球可用于制备特定尺寸的药物。
• Bioadhesive compositions and methods for topical administration of active agents
  申请人：NOVEN PHARMACEUTICALS, INC.

  公开号：US20040018241A1

  公开（公告）日：2004-01-29

  Bioadhesive compositions in a flexible, finite form for topical application to skin or mucous membranes comprising a composition which results from an admixture of at least one PVP polymer, at least one bioadhesive, optionally a pharmaceutically acceptable solvent suitable for use with an active agent, and methods of administering active agents to a subject, are disclosed. The bioadhesive composition can either include an active agent incorporated directly in the composition, or a separate source of an active agent.

  本发明公开了用于皮肤或粘膜局部应用的柔性、有限形式的生物粘附性组合物，该组合物由至少一种 PVP 聚合物、至少一种生物粘附剂、可选的适合与活性剂一起使用的药学上可接受的溶剂混合而成，并公开了向受试者施用活性剂的方法。生物粘合剂组合物既可以包括直接掺入组合物中的活性剂，也可以包括单独的活性剂来源。