N-ethyl-N-isopropyl-methanamide | 125342-83-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-ethyl-N-isopropyl-methanamide
• 英文别名: N-ethyl-N-isopropyl-formamide；N-ethyl-N-propan-2-ylformamide
• CAS: 125342-83-8
• 化学式: C₆H₁₃NO
• 分子量: 115.175
• InChiKey: AIMDBKBBUWLIPG-UHFFFAOYSA-N

物化性质

• 沸点：
  194.2±9.0 °C(Predicted)
• 密度：
  0.869±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  甲酸甲酯 、 N-乙基异丙基胺 在 1,5,7-三氮杂双环[4.4.0]癸-5-烯 作用下， 反应 96.0h， 以71%的产率得到N-ethyl-N-isopropyl-methanamide
  参考文献：
  名称：

  甲酸甲酯与胺的催化反应生成甲酰胺

  摘要：

  报道了使用甲酸甲酯作为廉价试剂以高收率将脂肪族和芳香族胺转化为甲酰胺的可行方法。改进的胺甲酰化方法主要在室温和以双环胍为催化剂的条件下进行。甲酸甲酯和反应混合物中的催化剂可生成具有出色甲酰化活性的可验证关键中间体。

  DOI：

  10.1016/j.tet.2009.10.047

文献信息

• [EN] AZOLINE COMPOUNDS<br/>[FR] COMPOSÉS AZOLINE
  申请人：BASF SE

  公开号：WO2015128358A1

  公开（公告）日：2015-09-03

  The present invention relates to azoline compounds of formula (I) wherein A, B1, B2, B3, G1, G2, X1, R1, R3a, R3b, Rg1 and Rg2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及式（I）的噁唑啉化合物，其中A、B1、B2、B3、G1、G2、X1、R1、R3a、R3b、Rg1和Rg2如权利要求和描述中所定义。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种利用这些化合物控制无脊椎动物害虫的方法，以及包括所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS<br/>[FR] NOUVEAUX COMPOSÉS SPIROHÉTÉROCYCLIQUES EN TANT QU'ANTAGONISTES DE MGLU5
  申请人：RECORDATI IRELAND LTD

  公开号：WO2012004400A1

  公开（公告）日：2012-01-12

  The invention provides compounds having the general formula (I) wherein X is O or S; R1 is C, N, O or S; R1a is CH, CH2, N or NH; R2 is a bond, CH or CH2; m is 1, 2 or 3; n is 1 or 2; when n is 2 or m is 2 or 3, the ring containing R1 may be fused with a benzene ring; each --- represents a single or double bond provided that one double bond extends from the carbon atom to which R3-C≡C- is bonded and that no ring carbon atom bears two double bonds; and R3, R4 and R5 represent a wide range of substituents. These compounds are selective for the metabotropic mGlu5 receptor. They, their solvates, hydrates, enantiomers, diastereomers, N-oxides and pharmaceutically acceptable salts, and pharmaceutical compositions containing them, can be used to treat diseases or disorders of the lower urinary tract, especially neuromuscular dysfunctions of the lower urinary tract. They may also be useful for the treatment of migraine; for the treatment of gastroesophageal reflux disease (GERD); for the treatment of anxiety disorder; for the treatment of abuse, substance dependence and substance withdrawal disorder; for the treatment of neuropathic pain disorder; and for the treatment of fragile X syndrome disorders.

  该发明提供了具有一般式（I）的化合物，其中X为O或S；R1为C、N、O或S；R1a为CH、CH2、N或NH；R2为键、CH或CH2；m为1、2或3；n为1或2；当n为2或m为2或3时，含有R1的环可能与苯环融合；每个---代表单键或双键，其中一个双键延伸自R3-C≡C-键合的碳原子，且没有环碳原子带有两个双键；R3、R4和R5代表各种取代基。这些化合物对代谢型mGlu5受体具有选择性。它们及其溶剂合物、水合物、对映体、非对映体异构体、N-氧化物和药学上可接受的盐，以及含有它们的药物组合物，可用于治疗下尿路的疾病或紊乱，特别是下尿路的神经肌肉功能紊乱。它们也可能对治疗偏头痛；治疗胃食管反流病（GERD）；治疗焦虑症；治疗滥用、物质依赖和物质戒断紊乱；治疗神经病性疼痛紊乱；以及治疗脆性X综合症紊乱有用。
• [EN] THIOPHENE- OR FURAN-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS AS PESTICIDES<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN THIOPHÈNE OU UN FURANE COMME PESTICIDES
  申请人：BASF SE

  公开号：WO2014206909A1

  公开（公告）日：2014-12-31

  The present invention relates to thiophene- or furan-substituted isothiazoline compounds of formula I wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及式I的噻吩或呋喃取代的异噻唑啉化合物，其中变量如权利要求和描述中所定义。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种通过使用这些化合物来控制无脊椎动物害虫的方法，以及包括所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] CYCLIC COMPOUNDS SUBSTITUTED BY A CONDENSED RING SYSTEM<br/>[FR] COMPOSÉS CYCLIQUES SUBSTITUÉS PAR UN SYSTÈME CYCLIQUE CONDENSÉ
  申请人：BASF SE

  公开号：WO2016102490A1

  公开（公告）日：2016-06-30

  The present invention relates to compounds of formula (I) wherein the variables are as defined in the claims and the description. The invention further relates to the use of these compounds for controlling invertebrate pests and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds. The invention also relates to novel compounds useful as intermediate compounds in the preparation of compounds (I).

  本发明涉及式(I)的化合物，其中变量如权利要求和描述中所定义。该发明还涉及利用这些化合物控制无脊椎动物害虫，以及包括所述化合物的植物繁殖材料、农业和兽医组合物。该发明还涉及作为化合物(I)制备中间化合物的新化合物。
• [EN] AZOLINE COMPOUNDS SUBSTITUTED BY A CARBOCYCLIC CONDENSED RING SYSTEM<br/>[FR] COMPOSÉS D'AZOLINE SUBSTITUÉS PAR UN SYSTÈME CARBOCYCLIQUE CONDENSÉ
  申请人：BASF SE

  公开号：WO2016102488A1

  公开（公告）日：2016-06-30

  The present invention relates to compounds of formula (I) wherein the variables are as defined in the claims and the description. The invention further relates to the use of these compounds for controlling invertebrate pests and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds. The invention also relates to novel compounds useful as intermediate compounds in the preparation of compounds I.

  本发明涉及式(I)的化合物，其中变量如权利要求和描述中所定义。该发明进一步涉及利用这些化合物控制无脊椎动物害虫，以及植物繁殖材料和包含所述化合物的农业和兽医组合物的用途。该发明还涉及作为化合物I制备中间化合物时有用的新化合物。