Methyl 3-methyl-2-sulfanylbutanoate | 67964-43-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl 3-methyl-2-sulfanylbutanoate
• CAS: 67964-43-6
• 化学式: C₆H₁₂O₂S
• 分子量: 148.226
• InChiKey: CVBYXSZGPCPKNA-UHFFFAOYSA-N

物化性质

• 沸点：
  186.1±13.0 °C(Predicted)
• 密度：
  1.016±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  27.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl 3-methyl-2-sulfanylbutanoate 、 3-溴-4-甲基戊-2-酮 以100%的产率得到
  参考文献：
  名称：

  YANO S.; NISHINO K.; NAKASUJI K.; MURATA I., CHEM. LETT., 1978, NO 7, 723-726

  摘要：

  DOI：

文献信息

• Stereoselective synthesis of anti-PAF active thiazolidin-4-ones via cyclo-condensation of alkyl α-mercaptocarboxylates with arylimines
  作者：Yoo Tanabe、Yoshi-no Kubota、Yuzuru Sanemitsu、Nobushige Itaya、Gohfu Suzukamo

  DOI：10.1016/s0040-4039(00)92634-0

  日期：1991.1

  Two distinctive methods for the synthesis of cis- and trans-2, 5-disubstituted-thiazolidin-4-ones via stereoselective cyclo-condensation between α-mercaptocarboxylic esters and arylimines have been developed. With the new reaction used as the key step, two sets of optically active anti-PAF active thiazolidin-4-ones were synthesized.

  已经开发出两种独特的方法，其通过α-巯基羧酸酯和芳胺的立体选择性环缩合合成顺式和反式-2，5-二取代-噻唑烷-4-酮。以新的反应为关键步骤，合成了两套光学活性的抗PAF活性噻唑烷酮-4-酮。
• PROCESS FOR PRODUCING (FLUOROALKYLTHIO) ACETIC ACID ESTER
  申请人：Hirota Masaji

  公开号：US20120101294A1

  公开（公告）日：2012-04-26

  Disclosed is a process for producing a (fluoroalkylthio)acetic acid ester represented by the formula (3) wherein R, R 1 and R 2 have the same meanings as defined below, which comprises reacting a thioglycolic acid ester represented by the formula (1) wherein R represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and R 1 represents an alkyl group having 1 to 4 carbon atoms, with fluoroolefin represented by the formula (2) wherein R 2 represents a fluoroalkyl group having 1 to 5 carbon atoms, in the presence of a radical generator.

  揭示了一种生产（氟烷基硫）乙酸酯的过程，其表示为式（3），其中R，R1和R2的含义如下定义，包括将由式（1）表示的巯基乙酸酯与由式（2）表示的氟烯烃在自由基发生剂存在下反应，其中R代表氢原子或具有1至5个碳原子的烷基基团，R1代表具有1至4个碳原子的烷基基团，R2代表具有1至5个碳原子的氟烷基基团。
• Thiolactam-n-acetic acid derivatives
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04771050A1

  公开（公告）日：1988-09-13

  Compounds of the general formula: ##STR1## wherein, R.sup.1 and R.sup.2 are, the same or different, hydrogen, a halogen, a lower alkyl, a cycloalkyl, a lower alkoxy, trifluoromethyl or a phenylalkyloxy whose phenyl ring may be substituted by one to three substituents selected from the group consisting of a halogen, a lower alkyl, a lower alkoxy, methylenedioxy and trifluoromethyl; R.sup.3 is hydrogen or methyl; R.sup.4 is carboxyl or an esterified carboxyl; and X is oxygen or sulfur, or a salt thereof. These compounds possess aldose reductase inhibitory and platelet aggregation inhibitory activities, and are of use as drugs for prevention and treatment of diabetic complications such as diabetic cataract, retinophathy, nephropathy, and neuropathy.

  一般式为：##STR1## 其中，R.sup.1和R.sup.2是相同或不同的氢、卤素、低碳基、环烷基、低烷氧基、三氟甲基或苯基烷氧基，其苯环可能被选自卤素、低碳基、低烷氧基、亚甲二氧基和三氟甲基的一至三个取代基取代；R.sup.3是氢或甲基；R.sup.4是羧基或酯化羧基；X是氧或硫，或其盐。这些化合物具有醛糖还原酶抑制和血小板聚集抑制活性，并可用作预防和治疗糖尿病并发症，如糖尿病白内障、视网膜病变、肾病和神经病变的药物。
• PROCESS FOR PREPARATION OF (FLUOROALKYLTHIO)ACETIC ACID ESTERS
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2465846A1

  公开（公告）日：2012-06-20

  Disclosed is a process for producing a (fluoroalkylthio)acetic acid ester represented by the formula (3) wherein R, R1 and R2 have the same meanings as defined below, which comprises reacting a thioglycolic acid ester represented by the formula (1) wherein R represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and R1 represents an alkyl group having 1 to 4 carbon atoms, with fluoroolefin represented by the formula (2) wherein R2 represents a fluoroalkyl group having 1 to 5 carbon atoms, in the presence of a radical generator.

  本发明公开了一种生产由式（3）表示的（氟烷硫基）乙酸酯的工艺，其中 R、R1 和 R2 具有与下文定义相同的含义，该工艺包括在自由基发生器存在的情况下，将由式（1）表示的硫代乙醇酸酯（其中 R 代表氢原子或具有 1 至 5 个碳原子的烷基，R1 代表具有 1 至 4 个碳原子的烷基）与由式（2）表示的氟烯烃（其中 R2 代表具有 1 至 5 个碳原子的氟烷基）反应。
• Process for producing amide compounds
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2664613A1

  公开（公告）日：2013-11-20

  Disclosed is a process for producing an amide compound of the formula (6): wherein R and R2 have the same meanings as defined below, and n represents 1 or 2, which comprises oxidizing a (fluoroalkylthio)acetamide of the formula (8): wherein R represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and R2 represents a fluorine-containing alkyl group having 1 to 5 carbon atoms. The carbamoyl group (-CONH2) of the amide compound of the formula (6) can be converted into a cyano group (-CN)to obtain a nitrile compound of the formula (7): wherein R, R2 and n have the same meanings as defined above.

  本发明公开了一种生产式（6）酰胺化合物的工艺： 其中 R 和 R2 与下文定义的含义相同，n 代表 1 或 2，该工艺包括氧化式（8）的（氟烷基硫代）乙酰胺： 其中 R 代表氢原子或具有 1 至 5 个碳原子的烷基，R2 代表具有 1 至 5 个碳原子的含氟烷基。式（6）酰胺化合物的氨基甲酰基（-CONH2）可转化为氰基（-CN），得到式（7）腈化合物： 其中 R、R2 和 n 的含义与上述定义相同。