tetradecyl (N,N-dimethylamino)acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tetradecyl (N,N-dimethylamino)acetate
• 英文别名: Tetradecyl 2-(dimethylamino)acetate
• 化学式: C₁₈H₃₇NO₂
• 分子量: 299.497
• InChiKey: DZUJSXDQZILVCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tetradecyl (N,N-dimethylamino)acetate 、 对硝基溴化苄 以 乙醚 为溶剂， 生成 Dimethyl-(4-nitro-benzyl)-tetradecyloxycarbonylmethyl-ammonium; bromide
  参考文献：
  名称：

  Thompson, Richard A.; Allemark, Stig, Acta Chemica Scandinavica, 1989, vol. 43, # 7, p. 690 - 693

  摘要：

  DOI：

文献信息

• Method of administration and treatment
  申请人：AMPERSAND BIOPHARMACEUTICALS, INC.

  公开号：US10639326B2

  公开（公告）日：2020-05-05

  Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.

  本文提供了用于局部和/或透皮给药的制剂，以及使用这些制剂治疗与癌症有关的增殖性疾病（如癌症和相关疾病以及实体瘤）的方法。还提供了用于局部和/或透皮给药的制剂，以及使用这些制剂治疗黄褐斑、痛风、皮肤病和本文所述的其他疾病和失调的方法，以及用于调节肿瘤近端组织或微环境的 pH 值（例如升高）、调节 pH 值或提高已知化疗药物、免疫疗法等的有效性以预防、治疗本文所述的癌症和相关疾病的方法。
• Transdermal carrier
  申请人：Ampersand Biopharmaceuticals, Inc.

  公开号：US10814003B2

  公开（公告）日：2020-10-27

  Improved formulations for topical treatment that ensure at least localized transdermal or systemic delivery of an active agent through skin, nails or hair follicles are disclosed.

  本发明公开了用于局部治疗的改进配方，可确保至少通过皮肤、指甲或毛囊局部透皮或全身输送活性剂。
• Transdermal penetrant formulations containing cannabidiol
  申请人：AMPERSAND BIOPHARMACEUTICALS, INC.

  公开号：US11026896B2

  公开（公告）日：2021-06-08

  Disclosed herein is a transdermal delivery formulation for transdermal delivery of a Cannabidiol, with or without one or more additional active agents through the dermis, including the skin, nail or hair follicle of a subject, wherein the formulation comprises a) a transdermal delivery formulation in an amount less than about 60% w/w, comprising i. one or more phosphatides, ii. glucose, and iii. one or more fatty acids; b) water in an amount less than about 50% w/w, a Cannabidiol with or within one or more additional active agents.

  本文公开了一种透皮给药配方，用于通过真皮（包括受试者的皮肤、指甲或毛囊）透皮给药大麻二酚（含或不含一种或多种额外活性剂），其中该配方包括 a) 含量小于约 60% w/w 的透皮给药配方，包含 i. 一种或多种磷脂，ii. 葡萄糖，iii. 一种或多种脂肪酸；b) 含量小于约 50% w/w 的水，大麻二酚（含或不含一种或多种额外活性剂）。
• Topical formulations containing erythritol and methods of treating skin conditions
  申请人：InnoMed Technologies, Inc.

  公开号：US11517578B1

  公开（公告）日：2022-12-06

  Embodiments include formulations and methods for topical administration of sugar alcohol to treat a skin condition such as acne. A formulation can include a moisturizer, an emollient, a sugar alcohol and zinc. The sugar alcohol can be erythritol. The erythritol can be administered with zinc chloride. The erythritol and zinc chloride can be formulated at a molar ratio of about 3:1. The methods can also include administration of a therapeutic amount of a second agent such as benzoyl peroxide or a retinoid.

  本发明的实施方案包括外用糖醇治疗痤疮等皮肤病的配方和方法。配方可包括保湿剂、润肤剂、糖醇和锌。糖醇可以是赤藓糖醇。赤藓糖醇可与氯化锌一起使用。赤藓糖醇和氯化锌的摩尔比约为 3:1。这些方法还可以包括施用治疗量的第二种药剂，如过氧化苯甲酰或维A酸。
• TOPICAL FORMULATIONS
  申请人：Nuvo Research Inc.

  公开号：EP2482850A2

  公开（公告）日：2012-08-08