(2,2-Dimethyl-3-propan-2-yloxypropyl) acetate | 73238-60-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2,2-Dimethyl-3-propan-2-yloxypropyl) acetate
• 英文别名: (2,2-dimethyl-3-propan-2-yloxypropyl) acetate
• CAS: 73238-60-5
• 化学式: C₁₀H₂₀O₃
• 分子量: 188.267
• InChiKey: ATWDJQAAJJIQTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,3-二甲基氧杂环丁烷 、 2-碘代丙烷 、 mercury(II) diacetate 反应 7.0h， 生成 (2,2-Dimethyl-3-propan-2-yloxypropyl) acetate
  参考文献：
  名称：

  汞（II）盐和烷基卤与环氧乙烷、氧杂环丁烷和四氢吡喃的开环反应

  摘要：

  伯和仲烷基卤化物与乙酸汞 (II) 在环氧乙烷、氧杂环丁烷和四氢吡喃中的反应导致开环，得到相应的烷氧基烷基乙酸酯。与氧杂环丁烷中硫氰酸汞 (II) 的类似反应得到烷氧基烷基异硫氰酸酯和硫氰酸酯、ROCH2C(R')2CH2NCS 和 ROCH2C(R')2CH2SCN，其中异构体比率（N/S 比率）为 82-96/4-18。这表明反应涉及三元、四元或六元 O-烷基氧鎓离子中间体的初始形成和随后的 XHgZ2- 攻击。

  DOI：

  10.1246/bcsj.52.3611

文献信息

• SUBSTITUTED NUCLEOTIDE ANALOGS
  申请人：Smith David Bernard

  公开号：US20120071434A1

  公开（公告）日：2012-03-22

  Disclosed herein are phosphorothioate nucleotide analogs, methods of synthesizing phosphorothioate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs.

  本文披露了磷酸硫代酯核苷类似物，合成磷酸硫代酯核苷类似物的方法，以及利用磷酸硫代酯核苷类似物治疗病毒感染、癌症和/或寄生虫病等疾病和/或症状的方法。
• CYCLIC NUCLEOTIDE ANALOGS
  申请人：ALIOS BIOPHARMA, INC.

  公开号：US20140303108A1

  公开（公告）日：2014-10-09

  Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.

  本文披露了环核苷酸类似物、合成环核苷酸类似物的方法以及使用环核苷酸类似物治疗病毒感染、癌症和/或寄生虫病等疾病和/或病况的方法。
• Solid Forms of a Thiophosphoramidate Nucleotide Prodrug
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20130266538A1

  公开（公告）日：2013-10-10

  The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents.
• SOLID FORMS OF A THIOPHOSPHORAMIDATE NUCLEOTIDE PRODRUG
  申请人：Alios BioPharma, Inc.

  公开号：US20150175647A1

  公开（公告）日：2015-06-25

  The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents.
• ANTIFOG COATING COMPOSITION AND METHOD OF MAKING THEREOF
  申请人：Karunakaran Raghuraman Govindan

  公开号：US20170204313A1

  公开（公告）日：2017-07-20

  The present technology relates to an antifog coating composition comprising a matrix, a hydrophilic compound, and a surfactant. The antifog coating composition may further comprise a thermal or a photo-initiator. The antifog coating composition may be applied to a polycarbonate substrate.