6-羟基-3-甲基吡啶-2-羧酸 | 115185-81-4

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 6-羟基-3-甲基吡啶-2-羧酸
• 中文别名: 1,6-二氢-3-甲基-6-氧代-2-吡啶羧酸
• 英文名称: 6-hydroxy-3-methylpicolinic acid
• 英文别名: 6-hydroxy-3-methyl-pyridine-2-carboxylic acid；6-Hydroxy-3-methyl-pyridin-2-carbonsaeure；3-methyl-6-oxo-1H-pyridine-2-carboxylic acid
• CAS: 115185-81-4
• 化学式: C₇H₇NO₃
• 分子量: 153.137
• InChiKey: WDZFYBWSAROMOO-UHFFFAOYSA-N

物化性质

• 熔点：
  290-300 °C (decomp)
• 沸点：
  410.4±45.0 °C(Predicted)
• 密度：
  1.345±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090
• 储存条件：
  储存温度为2-8°C，并需保存在惰性气体中。

反应信息

• 作为反应物：
  描述：

  6-羟基-3-甲基吡啶-2-羧酸 在 铜 作用下， 生成 2-羟基-5-甲基嘧啶
  参考文献：
  名称：

  The Synthesis of Certain Substituted 2,2'-Bipyridyls¹

  摘要：

  DOI：

  10.1021/ja01216a045
• 作为产物：
  描述：

  3-甲基-6-氧代-6H-吡喃-2-羧酸 在 ammonium hydroxide 作用下， 以 水 为溶剂， 以1 mg的产率得到6-羟基-3-甲基吡啶-2-羧酸
  参考文献：
  名称：

  Acromelic acids A and B. Potent neuroexcitatory amino acids isolated from Clitocybe acromelalga

  摘要：

  DOI：

  10.1021/ja00222a044

文献信息

• [EN] SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS<br/>[FR] COMPOSÉS DE PYRAZOLO[1,5-A]PYRIDINE SUBSTITUÉS EN TANT QU'INHIBITEURS DE LA KINASE RET
  申请人：ANDREWS STEVEN W

  公开号：WO2018071454A1

  公开（公告）日：2018-04-19

  Provided herein are compounds of the Formula I: (I) or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

  本文提供了Formula I的化合物：(I)或其药用可接受的盐或溶剂，其中A、B、X1、X2、X3、X4、环D、E、Ra、Rb、n和m的含义如规范中所述，它们是RET激酶的抑制剂，并且在治疗和预防可以用RET激酶抑制剂治疗的疾病中非常有用，包括与RET相关的疾病和紊乱。
• Stabilization of alkaline hydrogen peroxide
  申请人：Wang Xue

  公开号：US20050226800A1

  公开（公告）日：2005-10-13

  A stabilized basic aqueous hydrogen peroxide composition is disclosed. The composition contains about 0.3 wt % to about 15 wt % of hydrogen peroxide; water; and a stabilizer system that contains about 10 ppm to about 1% of a stannate stabilizer; 10 ppm to about 1% of a phosphonic acid chelating agent or a mixture of phosphonic acid chelating agents; and 10 ppm to about 1% of an aromatic chelating agent or a mixture of aromatic chelating agents. The composition comprises less than about 10 ppm pyrophosphate, preferably no pyrophosphate; and has a pH greater than 7.0, preferably about 8.0 to about 10.5.

  本发明公开了一种稳定的碱性过氧化氢水溶液组合物。该组合物含有约 0.3 重量百分比至约 15 重量百分比的过氧化氢；水；以及稳定剂体系，该稳定剂体系含有约 10 ppm 至约 1%的锡酸盐稳定剂；10 ppm 至约 1%的膦酸螯合剂或膦酸螯合剂混合物；以及 10 ppm 至约 1%的芳香族螯合剂或芳香族螯合剂混合物。该组合物包含小于约 10 ppm 的焦磷酸盐，最好不含焦磷酸盐；pH 值大于 7.0，最好约为 8.0 至约 10.5。
• Stabilized thickened hydrogen peroxide containing compositions
  申请人：Wang Xue

  公开号：US20060063695A1

  公开（公告）日：2006-03-23

  Stabilized thickened hydrogen peroxide containing compositions are disclosed. The compositions contain a stabilizer system made up of a stannate stabilizer, a phosphorus containing stabilizer or a mixture of phosphorus containing stabilizers; and an aromatic chelating agent or a mixture of aromatic chelating agents. The compositions are suitable for use as disinfectants, as cleaning agents, and in various personal care applications such as hair care and tooth whitening.

  本发明公开了含过氧化氢的稳定增稠组合物。该组合物含有由锡酸盐稳定剂、含磷稳定剂或含磷稳定剂混合物组成的稳定剂体系；以及芳香族螯合剂或芳香族螯合剂混合物。这些组合物适合用作消毒剂、清洁剂和各种个人护理用品，如护发和牙齿美白。
• Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor
  作者：Makoto Ando、Nagaaki Sato、Tsuyoshi Nagase、Keita Nagai、Shiho Ishikawa、Hirobumi Takahashi、Norikazu Ohtake、Junko Ito、Mioko Hirayama、Yuko Mitobe、Hisashi Iwaasa、Akira Gomori、Hiroko Matsushita、Kiyoshi Tadano、Naoko Fujino、Sachiko Tanaka、Tomoyuki Ohe、Akane Ishihara、Akio Kanatani、Takehiro Fukami

  DOI：10.1016/j.bmc.2009.05.069

  日期：2009.8

  A series of 2-pyridone-containing imidazoline derivatives was synthesized and evaluated as neuropeptide Y Y5 receptor antagonists. Optimization of the 2-pyridone structure on the 2-position of the imidazoline ring led to identification of 1-(difluoromethyl)-5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin- 3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl] pyridin-2(1H)-one (7m). Compound 7m displayed statistically significant inhibition of food intake in an agonist-induced food intake model in SD rats and no adverse cardiovascular effects in anesthetized dogs. In addition, markedly higher brain penetrability and a lower plasma Occ90 value were observed in P-gp-deficient mdr1a (-/-) mice compared to mdr1a (+/+) mice after oral administration of 7m. (C) 2009 Elsevier Ltd. All rights reserved.
• STUDIES ON LACTONES RELATED TO THE CARDIAC AGLYCONES. V. SYNTHESIS OF 5-ALKYL-α-PYRONES
  作者：JOSEF FRIED、ROBERT C. ELDERFIELD

  DOI：10.1021/jo01204a010

  日期：1941.7