US8889696, Staurosporine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: US8889696, Staurosporine
• 英文别名: (3R,4R)-3-methoxy-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
• 化学式: C₂₇H₂₄N₄O₃
• 分子量: 452.5
• InChiKey: YISMQBFJYDFMAL-AESIHLKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  34
• 可旋转键数：
  2
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  69.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] ENHANCED DIFFERENTIATION OF BETA CELLS<br/>[FR] DIFFÉRENCIATION AMÉLIORÉE DE CELLULES BÊTA
  申请人：[en]VERTEX PHARMACEUTICALS INCORPORATED

  公开号：WO2022147056A1

  公开（公告）日：2022-07-07

  Provided herein are, inter alia, compositions and methods for improved production of SC-β cells in vitro. For example, provided are novel formulations and differentiation methods that result in higher cell yields and recoveries, increased numbers and relative percentages of SC-β cells, enhanced stability and shelf-life of SC-β cells, SC-islet clusters with advantageous characteristics such as reduced size and increased uniformity, improved function of the SC-β cells in vitro, and improved viability, function, and reduced immunogenicity after transplantation. The disclosed compositions and methods can be employed in the manufacture of SC-islets for human therapeutic use.