6-苯基甲氧基吡嗪-2-胺 | 126993-72-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 6-苯基甲氧基吡嗪-2-胺
• 英文名称: 2-amino-6-benzyloxypyrazine
• 英文别名: 6-(Benzyloxy)pyrazin-2-amine；6-phenylmethoxypyrazin-2-amine
• CAS: 126993-72-4
• 化学式: C₁₁H₁₁N₃O
• 分子量: 201.228
• InChiKey: ZSRANPPJBKMMSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-6-氯吡嗪 、 苯甲醇 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.5h， 以19%的产率得到6-苯基甲氧基吡嗪-2-胺
  参考文献：
  名称：

  WO2019204816A5

  摘要：

  公开号：

  WO2019204816A5

文献信息

• Compounds useful for inhibiting Chk1
  申请人：——

  公开号：US20030069284A1

  公开（公告）日：2003-04-10

  Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

  公开了芳基和杂芳基取代脲化合物，用于治疗与DNA损伤或DNA复制中DNA损伤有关的疾病和状况。还公开了制造这些化合物的方法，以及它们作为治疗剂的使用，例如，在治疗由DNA复制、染色体分离或细胞分裂缺陷引起的癌症和其他疾病。
• [EN] ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHAMOSENSITIZERS<br/>[FR] UREE ARYLE ET HETEROARYLE UTILISEE EN TANT QU'INHIBITEUR DE CHK1, A UTILISER EN TANT QUE RADIOSENSIBILISANTS ET CHIMIOSENSIBILISANTS
  申请人：ICOS CORP

  公开号：WO2002070494A1

  公开（公告）日：2002-09-12

  Aryl- and heteroaryl substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed. Wherein W' is a six-membered aromatic ring containing at least 2 introgen atoms and optionally substitutedas defined in the claims, Z' is a five- or six membered aromatic or heteraromatic ring as defined in the claims, Y' is O or S.

  本发明涉及芳基和杂芳基取代的脲类化合物，用于治疗与DNA损伤或DNA复制中的损伤有关的疾病和病况。本发明还公开了制备这些化合物的方法以及它们作为治疗剂的用途，例如治疗癌症和其他以DNA复制缺陷、染色体分离或细胞分裂为特征的疾病。其中W'是一个含有至少2个氮原子的六元芳环，也可以是根据权利要求中定义的取代基；Z'是根据权利要求中定义的五元或六元芳香环或杂芳香环；Y'是O或S。
• Compounds useful for inhibiting CHK1
  申请人：Keegan S. Kathleen

  公开号：US20050245525A1

  公开（公告）日：2005-11-03

  Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

  本文披露了芳基和杂环芳基取代的脲类化合物，其可用于治疗与DNA损伤或DNA复制中的损伤相关的疾病和病症。本文还披露了制备这些化合物的方法，以及它们作为治疗剂的用途，例如治疗癌症和其他由DNA复制缺陷、染色体分离或细胞分裂引起的疾病。
• COMPOUNDS USEFUL FOR INHIBITING CHK1
  申请人：Keegan Kathleen S.

  公开号：US20100105683A1

  公开（公告）日：2010-04-29

  Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

  本发明公开了用于治疗与DNA损伤或DNA复制中的损伤有关的疾病和病症的芳基和杂环基取代脲化合物。本发明还公开了制备该化合物的方法以及它们作为治疗剂的用途，例如，在治疗癌症和其他以DNA复制缺陷、染色体分离或细胞分裂为特征的疾病中。
• Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1
  申请人：Icos Corporation

  公开号：US07608618B2

  公开（公告）日：2009-10-27

  Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of wherein Q′ is OR7 and R7 is C1-3alkyleneC3-8heterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

  本发明公开了化合物的公式，其中：Y′为O或S，W′为可选取代基，Z′选自以下组中：其中Q′为OR7，R7为C1-3烷基C3-8杂环烷基，有助于治疗与DNA损伤或DNA复制中的损伤有关的疾病和状况。本发明还公开了制备这些化合物的方法，以及它们作为治疗剂的用途，例如，用于治疗癌症和其他以DNA复制缺陷，染色体分离或细胞分裂为特征的疾病。