N--pyrrolidin | 90727-01-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N--pyrrolidin
• 英文别名: 1-(Tert-butylperoxymethyl)pyrrolidine
• CAS: 90727-01-8
• 化学式: C₉H₁₉NO₂
• 分子量: 173.255
• InChiKey: CNJTUGODXHERGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 叔丁基过氧化氢 、 聚合甲醛 以 甲醇 、 水 为溶剂， 反应 4.0h， 生成 N--pyrrolidin
  参考文献：
  名称：

  Antimalarial t-butylperoxyamines

  摘要：

  Twelve t-butylperoxyamines (6 17) were synthesized as targeted antimalarials and evaluated for antimalarial activity in vivo against Plasmodium berghei in mice and in vitro against both chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum. Compound 8 was found to have highest potency with activity at 80 and 160 mg/kg dose in vivo and compound I I exhibited highest efficacy in vitro. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00396-1

文献信息

• Antimalarial t-butylperoxyamines
  作者：N Sundar、V.T Jacob、Sujata V Bhat、Neena Valecha、Sukla Biswas

  DOI：10.1016/s0960-894x(01)00396-1

  日期：2001.9

  Twelve t-butylperoxyamines (6 17) were synthesized as targeted antimalarials and evaluated for antimalarial activity in vivo against Plasmodium berghei in mice and in vitro against both chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum. Compound 8 was found to have highest potency with activity at 80 and 160 mg/kg dose in vivo and compound I I exhibited highest efficacy in vitro. (C) 2001 Elsevier Science Ltd. All rights reserved.