2-(4-oxopentanoyloxy)ethyl methacrylate | 251960-15-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2-(4-oxopentanoyloxy)ethyl methacrylate
• 英文别名: 2-(2-Methylprop-2-enoyloxy)ethyl 4-oxopentanoate
• CAS: 251960-15-3
• 化学式: C₁₁H₁₆O₅
• 分子量: 228.245
• InChiKey: UZFRSVWBPXUPGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲基丙烯酸羟乙酯 、 乙酰丙酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 以95%的产率得到2-(4-oxopentanoyloxy)ethyl methacrylate
  参考文献：
  名称：

  Keto-Functionalized Polymer Scaffolds as Versatile Precursors to Polymer Side-Chain Conjugates

  摘要：

  A new methacrylate monomer with a reactive ketone side chain, 2-(4-oxopentanoate)ethyl methacrylate (PAEMA), was synthesized and subsequently polymerized by reversible addition-fragmentation chain transfer (RAFT) polymerization to give a polymer with a narrow molecular weight distribution (PDI = 1.25). The polymer was chain extended with poly(ethylene glycol methyl ether methacrylate) (PEGMA) to yield a block copolymer. Aminooxy-containing small molecules and oligoethylene glycol were conjugated to the ketone functionality of the side chains in high yields. Cytotoxicity of the oxime-linked tetra(ethylene glycol) polymer to mouse fibroblast cells was investigated; the polymer was found to be noncytotoxic up to 1 mg/mL. The ease with which this polymer is functionalized suggests that it may be useful in forming tailored polymeric medicines.

  DOI：

  10.1021/ma302183g

文献信息

• Photochromic compositions and articles comprising siloxane, alkylene or substituted alkylene oligomers
  申请人：Evans Alexander Richard

  公开号：US20070187656A1

  公开（公告）日：2007-08-16

  This invention relations to a polymerizable composition for forming a photochromic article of glass transition temperature of at least 50 ° C. on curing, the composition comprising: (a) a polymerizable composition comprising a monomer component or resin formed therefrom; and (b) a photochromic dye monomer comprising a photochromic moiety and at least one oligomeric group having at least one group reactive with the monomer component during or following curing wherein the oligomer group comprises a multiplicity of monomer units selected from siloxane, alkylene and substituted alkylene.

  本发明涉及一种可聚合组合物，用于形成玻璃化转变温度至少为50℃的光致变色物品，所述组合物包括：(a)一种聚合物组合物，包括单体组分或由其形成的树脂；以及(b)一种光致变色染料单体，包括一个光致变色基团和至少一个具有至少一个与单体组分在固化期间或固化后反应的寡聚物基团，其中寡聚物基团包括从硅氧烷、烷基和取代烷基中选择的多种单体单元。
• Photochromic Compositions and Articles Comprising Polyether Oligomer
  申请人：Evans Alexander Richard

  公开号：US20070249794A1

  公开（公告）日：2007-10-25

  This invention relates to a polymerizable composition for forming a photochromic article having a glass transition temperature of at least 50° C. on curing the composition comprising: (a) a polymerizable composition comprising a monomer component; and (c) a photochromic dye monomer comprising a photochromic moiety and at least one oligomer group having at least one group reactive with the monomer component during curing wherein the oligomer group comprises at least seven polyether monomer units selected from alkylenoxy and haloalkylenoxy.
• Polyalkyl (Meth) Acrylate Copolymers Having Outstanding Properties
  申请人：Mueller Michael

  公开号：US20080146475A1

  公开（公告）日：2008-06-19

  (EN) The present invention relates to copolymers obtainable by polymerizing a monomer composition composed of a) 0% to 40% by weight of one or more ethylenically unsaturated ester compounds of the formula (I) in which R is hydrogen or methyl, R1 is a linear or branched alkyl radical having 1 to 5 carbon atoms, R 2 and R 3 independently are hydrogen or a group of the formula —COOR′, in which R 1 is hydrogen or an alkyl group having 1 to 5 carbon atoms, b) 10% to 99.9% by weight of one or more ethylenically unsaturated ester compounds of the formula (II) in which R is hydrogen or methyl, R 4 is a linear or branched alkyl radical having 6 to 15 carbon atoms, R 5 and R 6 independently are hydrogen or a group of the formula —COOR′, in which R′ is hydrogen or an alkyl group having 6 to 15 carbon atoms, c) 0% to 80% by weight of one or more ethylenically unsaturated ester compounds of the formula (III) in which R is hydrogen or methyl, R 7 is a linear or branched alkyl radical having 16 to 30 carbon atoms, R 8 and R 9 independently are hydrogen or a group of the formula —COOR″, in which R″ is hydrogen or an alkyl group having 16 to 30 carbon atoms, d) 0.1% to 30% by weight of one or more ethylenically unsaturated, polar ester compounds of the formula (IV) in which R is hydrogen or methyl, X is oxygen, sulphur or an amino group of the formula —NH— or —NR a —, in which Ra is an alkyl radical having 1 to 40 carbon atoms, R 10 is a radical which encompasses 2 to 1000 carbon atoms and has at least 2 heteroatoms, R 11 and R12 independently are hydrogen or a group of the formula —COX′R 10′ , in which X′ is oxygen or an amino group of the formula —NH— or —NR a —, in which R a′ is an alkyl radical having 1 to 40 carbon atoms, and R 10′ is a radical which encompasses 1 to 100 carbon atoms, and e) 0% to 50% by weight of comonomer, based in each case on the total weight of the ethylenically unsaturated monomers.
• Loading quantum dots into thermo-responsive microgels by reversible transfer from organic solvents to water
  申请人：Pich Andrij

  公开号：US20100025640A1

  公开（公告）日：2010-02-04

  Method for the preparation of inorganic-NP-composite microgels is based on the reversible transfer of microgels between water and an organic solvent such as tetrahydrofuran (THF). The method is used to produce semiconductor nanocrystals, often referred to as quantum dots (QDs) which are well known for their unique optical, electrical, magnetic and catalytic properties, as the inorganic NPs, recognizing that the best quality QDs are synthesized by a high temperature process in organic media, and have their surface covered with hydrophobic ligands (such as trioctylphosphine oxide, TOPO) that render the NPs insoluble in an aqueous solution.
• LOADING QUANTUM DOTS INTO THERMO-RESPONSIVE MICROGELS BY REVERSIBLE TRANSFER FROM ORGANIC SOLVENTS TO WATER
  申请人：Winnik Mitchell Alan

  公开号：US20110186782A1

  公开（公告）日：2011-08-04

  Method for the preparation of inorganic-NP-composite microgels is based on the reversible transfer of microgels between water and an organic solvent such as tetrahydrofuran (THF). The method is used to produce semiconductor nanocrystals, often referred to as quantum dots (QDs) which are well known for their unique optical, electrical, magnetic and catalytic properties, as the inorganic NPs, recognizing that the best quality QDs are synthesized by a high temperature process in organic media, and have their surface covered with hydrophobic ligands (such as trioctylphosphine oxide, TOPO) that render the NPs insoluble in an aqueous solution.