3-[4-(2-Carbazol-9-ylethoxy)phenyl]-2-ethoxypropanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[4-(2-Carbazol-9-ylethoxy)phenyl]-2-ethoxypropanoic acid
• 化学式: C₂₅H₂₅NO₄
• 分子量: 403.5
• InChiKey: WUZIMDSVRIBNNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  60.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] CHROMAN CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES AND LIPID DISORDERS<br/>[FR] DERIVES D'ACIDE CHROMANCARBOXYLIQUE UTILISES DANS LE TRAITEMENT DU DIABETE ET DES TROUBLES LIPIDIQUES
  申请人：SK CORP

  公开号：WO2005021540A1

  公开（公告）日：2005-03-10

  The invention is concerned with the 3-chromancarboxylic acid derivatives, their pharmaceutically acceptable salts and prodrugs which are useful for treatment and control of non-insulin dependent diabetes mellitus (type II diabetes) and its related vascular disease as well as obesity and lipid disorders.

  这项发明涉及3-色胺羧酸衍生物，它们的药用盐和前药，用于治疗和控制非胰岛素依赖型糖尿病（2型糖尿病）及其相关血管疾病，以及肥胖和脂质紊乱。
• Chroman carboxylic acid derivatives for the treatment of diabetes and lipid disorders
  申请人：Choi Moon Yong

  公开号：US20050107371A1

  公开（公告）日：2005-05-19

  There are disclosed derivatives of 3-chromancarboxylic acid represented by formula I their pharmaceutically acceptable salts thereof and prodrugs thereof which are useful for treatment and control of non-insulin dependent diabetes mellitus (type II diabetes) and its related vascular disease as well as obesity and lipid disorders

  本发明公开了3-香豆酸衍生物，其化学式为I，以及其药学上可接受的盐和前药。这些衍生物对治疗和控制非胰岛素依赖性糖尿病（2型糖尿病）及其相关的血管疾病、肥胖和脂质紊乱具有用处。
• Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use
  申请人：Choi Moon Yong

  公开号：US20060281802A1

  公开（公告）日：2006-12-14

  The present invention is concerned with racemic or enantiomerically enriched substituted carboxylic acids and derivatives thereof represented by Formula 1; or pharmaceutically acceptable salts thereof. The present invention also includes pharmaceutical compositions comprising an effective amount of a compound of Formula 1 in admixture with a pharmaceutically acceptable carrier or excipient. The compositions may include additional therapeutic agents for combination therapy. The present invention provides a new class of pharmaceutically active compounds, which are useful in the treatment and control of diabetes and its related metabolic diseases.

  本发明涉及由公式1所表示的外消旋或对映富集的取代羧酸及其衍生物，或其药学上可接受的盐。本发明还包括含有公式1化合物的有效量与药学上可接受的载体或赋形剂混合的制药组合物。该组合物可以包括其他治疗剂用于联合治疗。本发明提供了一类新的药理活性化合物，其在糖尿病及其相关代谢性疾病的治疗和控制中具有用处。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• AGENTS FOR TREATMENT OF ALCOHOL USE DISORDER
  申请人：Servicio Andaluz de Salud

  公开号：EP3834888A2

  公开（公告）日：2021-06-16

  The present invention relates to the use of PPARα agonist compounds for preventing, alleviating, improving and/or treating alcohol use disorder.

  本发明涉及 PPARα 激动剂化合物在预防、减轻、改善和/或治疗酒精使用障碍方面的用途。