2-Amino-1-[4-(2-chlorophenoxy)piperidin-1-yl]ethanone | 944240-55-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-1-[4-(2-chlorophenoxy)piperidin-1-yl]ethanone
• CAS: 944240-55-5
• 化学式: C₁₃H₁₇ClN₂O₂
• 分子量: 268.743
• InChiKey: ZYFRBEJYRHBUSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Amino-1-[4-(2-chlorophenoxy)piperidin-1-yl]ethanone 在 N-甲基吡咯烷酮 、 DIABL-H 、 三乙胺 作用下， 生成 3-[[2-[4-(2-Chlorophenoxy)piperidin-1-yl]-2-oxoethyl]amino]pyrazine-2-carbaldehyde
  参考文献：
  名称：

  Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors

  摘要：

  A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valuable for generation of proprietary compounds without conducting a costly high-throughput screening. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.099
• 作为产物：
  描述：

  [2-(4-Hydroxy-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 在 盐酸 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-Amino-1-[4-(2-chlorophenoxy)piperidin-1-yl]ethanone
  参考文献：
  名称：

  Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors

  摘要：

  A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valuable for generation of proprietary compounds without conducting a costly high-throughput screening. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.099

文献信息

• NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
  申请人：Bischoff Alexander

  公开号：US20100160323A1

  公开（公告）日：2010-06-24

  The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

  本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。该发明还涉及制备这些化合物的方法、含有这些化合物的组合物，以及使用这些化合物进行治疗的方法。
• METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Yumanity Therapeutics

  公开号：US20180193325A1

  公开（公告）日：2018-07-12

  The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

  本公开提供了在治疗神经系统疾病方面有用的化合物和方法。本发明的化合物可以单独或与其他药用活性剂结合使用，用于治疗或预防神经系统疾病。
• Methods for the treatment of neurological disorders
  申请人：Yumanity Therapeutics, Inc.

  公开号：US10973810B2

  公开（公告）日：2021-04-13

  The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

  本公开提供了用于治疗神经系统疾病的化合物和方法。本发明的化合物可单独使用或与其他药物活性剂结合使用，用于治疗或预防神经系统疾病。
• US8129376B2
  申请人：——

  公开号：US8129376B2

  公开（公告）日：2012-03-06
• [EN] NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE<br/>[FR] NOUVEAUX DÉRIVÉS DE PIPÉRIDINE SERVANT D'INHIBITEURS DE STÉAROYLE-COA-DÉSATURASE
  申请人：FOREST LAB HOLDINGS LTD

  公开号：WO2009117676A2

  公开（公告）日：2009-09-24

  The present invention relates to piperidine derivatives that act as inhibitors of stearoyl- CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.