2,2,2-trifluoroethyl 3-(2,5-dihydro-3-methoxy-5-oxo-1H-pyrrol-2-yl)propanoate | 1099824-59-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2,2-trifluoroethyl 3-(2,5-dihydro-3-methoxy-5-oxo-1H-pyrrol-2-yl)propanoate
• 英文别名: 2,2,2-Trifluoroethyl 3-(3-methoxy-5-oxo-1,2-dihydropyrrol-2-yl)propanoate；2,2,2-trifluoroethyl 3-(3-methoxy-5-oxo-1,2-dihydropyrrol-2-yl)propanoate
• CAS: 1099824-59-5
• 化学式: C₁₀H₁₂F₃NO₄
• 分子量: 267.205
• InChiKey: AWXIEYUGYBRCRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-甲氧基-3-吡咯啉-2-酮 、 丙烯酸三氟乙酯 在 三氟甲磺酸三甲基硅酯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以54%的产率得到2,2,2-trifluoroethyl 3-(2,5-dihydro-3-methoxy-5-oxo-1H-pyrrol-2-yl)propanoate
  参考文献：
  名称：

  Direct-type vinylogous Mukaiyama–Michael addition reactions involving pyrrolinone donors

  摘要：

  The direct Mukaiyama-Michael addition of vinylogous tetramate donors to a number of different Michael acceptors has been easily executed, by employing the TMSOTf/Et3N Mixture as soft Lewis acid/base promoter agent. Richly functionalized, highly manipulable gamma-substituted pyrrolinone products were practically synthesized in acceptable to excellent yields, and with diastereoselectivities heavily relying upon the substituent at the nitrogen atom of the pyrrolinone donor. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.10.007

文献信息

• Direct-type vinylogous Mukaiyama–Michael addition reactions involving pyrrolinone donors
  作者：Andrea Sartori、Claudio Curti、Lucia Battistini、Paola Burreddu、Gloria Rassu、Giorgio Pelosi、Giovanni Casiraghi、Franca Zanardi

  DOI：10.1016/j.tet.2008.10.007

  日期：2008.12

  The direct Mukaiyama-Michael addition of vinylogous tetramate donors to a number of different Michael acceptors has been easily executed, by employing the TMSOTf/Et3N Mixture as soft Lewis acid/base promoter agent. Richly functionalized, highly manipulable gamma-substituted pyrrolinone products were practically synthesized in acceptable to excellent yields, and with diastereoselectivities heavily relying upon the substituent at the nitrogen atom of the pyrrolinone donor. (C) 2008 Elsevier Ltd. All rights reserved.