3-tert-butylphenylhydrazine | 83672-24-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-tert-butylphenylhydrazine
• 英文别名: (3-tert-Butyl-phenyl)-hydrazin；3-t-butylphenylhydrazine；(3-Tert-butylphenyl)hydrazine
• CAS: 83672-24-6
• 化学式: C₁₀H₁₆N₂
• mdl: MFCD18434404
• 分子量: 164.25
• InChiKey: PTKZJYULUCGVRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-tert-butylphenylhydrazine 在 碳酸氢钠 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 4-{N'-[1-(3-tert-butyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
  参考文献：
  名称：

  Hydrazinonaphthalene and Azonaphthalene Thrombopoietin Mimics Are Nonpeptidyl Promoters of Megakaryocytopoiesis

  摘要：

  High-throughput screening for the induction of a luciferase reporter gene in a thrombopoietin (TPO)-responsive cell line resulted in the identification of 4-diazo-3-hydroxy-1-naphthalene-sulfonic acids as TPO mimics. Modification of the core structure and adjustment of unwanted functionality resulted in the development of (5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazines which exhibited efficacies equivalent to those of TPO in several cell-based assays designed to measure thrombopoietic activity. Furthermore, these compounds elicited biochemical responses in TPO-receptor-expressing cells similar to those in TPO itself, including kinase activation and protein phosphorylation. Potencies for the best compounds were high for such low molecular weight compounds (MW < 500) with EC50 values in the region of 1-20 nM.

  DOI：

  10.1021/jm010283l
• 作为产物：
  描述：

  3-叔丁基苯胺盐酸盐 、 sodium nitrite 在 stannous chloride dihydrate 、 盐酸 、 氯化钠 作用下， 以 盐酸 、 水 为溶剂， 反应 2.0h， 以to give 3-t-butylphenylhydrazine, b.p. 88°-90°/0.25 mm Hg的产率得到3-tert-butylphenylhydrazine
  参考文献：
  名称：

  Use of 3-(arylmethyleneamino)-1-aryl-2-pyrazolines in the prophylaxis

  摘要：

  分子式为（I）的化合物抑制花生四烯酸氧化的环氧合酶和脂氧合酶途径，并可作为医药上的抗炎和抗哮喘剂使用。这些化合物可以作为原始化学物质或与载体结合作为制药配方进行给药。这些化合物可以通过类似于艺术中已知的方法，例如Duffin和Kendall在J. Chem. Soc. (1954), 408-415的方法或其他方法进行制备。

  公开号：

  US04572913A1

文献信息

• CYTOKINE INHIBITORS
  申请人：Boman Erik

  公开号：US20100093734A1

  公开（公告）日：2010-04-15

  The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.

  本发明提供了低分子量化合物，可用作细胞因子抑制剂及其组合物。特别是，本发明的化合物可用作抗炎剂。还提供了制备这种药剂的方法，以及其在预防或治疗由细胞因子介导的疾病，如关节炎方面的用途。
• ALPHA-KETOAMIDES AND DERIVATIVES THEREOF
  申请人：Boman Erik

  公开号：US20100273797A1

  公开（公告）日：2010-10-28

  The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions medicated by cytokines such as arthritis.

  本发明提供了低分子量化合物，可用作细胞因子抑制剂及其组合物。特别地，本发明的化合物可用作抗炎剂。还提供了制备这些药剂的方法，并将其用于预防或治疗由细胞因子介导的疾病，例如关节炎。
• Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF₂H‐Bearing N‐Heterocycles
  作者：Anaïs Loison、Gilles Hanquet、Fabien Toulgoat、Thierry Billard、Armen Panossian、Frédéric R. Leroux

  DOI：10.1002/ejoc.202300695

  日期：2023.11.7

  A straightforward synthesis of nitrogen-containing heterocycles bearing the Emerging Fluorinated Group −OCF2H is herein disclosed. Various difluoromethoxylated pyrazoles, isoxazoles, pyrimidines and indoles were thus quickly and easily obtained. These new structures of high value were accessed from simple α-(difluoromethoxy)ketones as versatile building blocks in a one-pot process.

  本文公开了带有新兴氟化基团-OCF 2 H的含氮杂环的直接合成。由此快速且容易地获得各种二氟甲氧基化吡唑、异恶唑、嘧啶和吲哚。这些高价值的新结构是通过简单的 α-（二氟甲氧基）酮作为多功能构建单元在一锅法中获得的。
• Pyrazoline derivatives, processes for their preparation and pharmaceutical formulations containing them
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0056466A2

  公开（公告）日：1982-07-28

  Compounds of formula (I) inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and anti-asthmatic agents. The compounds may be administered as the raw chemical or in association with a carrier as a pharmaceutical formulation. The compounds may be prepared by methods analogous to those known in the art, e.g., by the method of Duffin and Kendall in J. Chem. Soc. (1954), 408-415, or by other methods.

  式（I）化合物 可抑制花生四烯酸氧合的环氧化酶和脂氧化酶途径，可作为消炎药和抗哮喘药等药物使用。 这些化合物可以作为化学原料给药，也可以与载体一起作为药物制剂给药。 这些化合物的制备方法可以类似于本领域已知的方法，例如 Duffin 和 Kendall 在 J. Chem.Soc.（1954），408-415）中的方法或其他方法制备。
• US4572913A
  申请人：——

  公开号：US4572913A

  公开（公告）日：1986-02-25