7-(二乙基氨基)-3-(5-苯基-1,3,4-噻二唑-2-基)-2-苯并吡喃酮 | 62143-26-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 7-(二乙基氨基)-3-(5-苯基-1,3,4-噻二唑-2-基)-2-苯并吡喃酮
• 中文别名: 7-(二乙基氨基)-3-(5-苯基-1,3,4-噻二唑-2-基)-2H-1-苯并吡喃-2-酮
• 英文名称: 3-<5'-Phenyl-thiadiazolyl-(2')>-7-diaethylamino-cumarin
• 英文别名: 7-diethylamino-3-(5-phenyl-[1,3,4]thiadiazol-2-yl)-chromen-2-one；7-(diethylamino)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)-2-benzopyrone；2H-1-Benzopyran-2-one, 7-(diethylamino)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)-；7-(diethylamino)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)chromen-2-one
• CAS: 62143-26-4
• 化学式: C₂₁H₁₉N₃O₂S
• 分子量: 377.467
• InChiKey: JBYNUUNOLLCWRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  83.6
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 海关编码：
  2934999090

反应信息

• 作为产物：
  描述：

  7-(二乙胺基)香豆素-3-甲酸乙酯 在 劳森试剂 、 一水合肼 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 25.2h， 生成 7-(二乙基氨基)-3-(5-苯基-1,3,4-噻二唑-2-基)-2-苯并吡喃酮
  参考文献：
  名称：

  Fluorescent Labeling Reagents. Part 3. Screening Search for Organic Fluorophores: Syntheses and Fluorescence Properties of 3-Azolyl-7-diethylaminocoumarin Derivatives.

  摘要：

  为了寻找高度敏感的荧光探针，合成了3-杂唑基-7-二乙氨基香豆素衍生物。这些香豆素-噻唑化合物的吸收和荧光最大值均表现出红移，相比于相应的香豆素-噁唑化合物，其摩尔吸光度和荧光强度均有所增加。其中，3-(5-乙氧基羧基-1, 3-噻唑-2-基)-7-二乙氨基-2H-香豆素-2-酮（3e）是作为分析用途的荧光探针中最有前途的候选者之一，适用于分析化学和生物化学领域。

  DOI：

  10.1248/cpb.48.1702

文献信息

• COMPOSITION FOR THE TREATMENT OF NAIL FUNGUS
  申请人：Oystershell NV

  公开号：EP3884933A1

  公开（公告）日：2021-09-29

  The current invention relates to a composition for the topical treatment of fungal infections in nails, comprising at least one physiologically acceptable carboxylic acid capable of reducing the pH in keratinous tissue, in particular nails, of a treated person below 4.0, preferably in the range of 1.5 - 4.0, a physiologically acceptable carrier comprising at least one C1-C4 alkyl ester of lactic acid, and at least one physiologically acceptable fluorescent whitening agent. The invention relates to the use of said composition for the preparation of a product suitable for treatment of fungal infections. The invention also relates to the use of said composition for the treatment of a fungal infection.

  本发明涉及一种用于局部治疗指甲真菌感染的组合物，该组合物包含至少一种生理上可接受的羧酸，该羧酸能够将受治疗者的角质组织（尤其是指甲）中的 pH 值降至 4.0 以下，最好在 1.5 - 4.0 之间；一种生理上可接受的载体，该载体包含至少一种乳酸的 C1-C4 烷基酯；以及至少一种生理上可接受的荧光增白剂。本发明涉及使用所述组合物制备适用于治疗真菌感染的产品。本发明还涉及使用所述组合物治疗真菌感染。
• MOULDED OBJECT EXHIBITING A POLYCHROMATIC EFFECT, ASSOCIATED LIGHT DEVICE AND RESIN
  申请人：Arkema France

  公开号：EP1848763A1

  公开（公告）日：2007-10-31
• Moulded Object Exhibiting a Polychromatic Effect, Associated Light Device and Resin
  申请人：Peter Vlottes

  公开号：US20080214706A1

  公开（公告）日：2008-09-04

  The present invention relates to a moulded object made of a transparent and coloured plastic exhibiting a polychromatic effect, characterized in that the transparent plastic comprises from 0.1 to 1500 ppm of at least one fluorescent dye and from 50 to 10 000 ppm of at least one optical brightener. It also relates to the resin used for forming the moulded object. It also relates to a light device combining the said moulded object with at least one artificial light source which exhibits an emission in the region of excitation of the optical brightener, in particular in the 300-450 nm range, preferably 350-420 nm range, more preferably still 350-400 nm range.
• [EN] MOULDED OBJECT EXHIBITING A POLYCHROMATIC EFFECT, ASSOCIATED LIGHT DEVICE AND RESIN<br/>[FR] OBJET MOULE PRESENTANT UN EFFET POLYCHROMATIQUE, DISPOSITIF D'ECLAIRAGE ET RESINE ASSOCIES
  申请人：ARKEMA FRANCE

  公开号：WO2006087241A1

  公开（公告）日：2006-08-24

  [EN] The present invention relates to a moulded object made of a transparent and coloured plastic exhibiting a polychromatic effect, characterized in that the transparent plastic comprises from 0.1 to 1500 ppm of at least one fluorescent dye and from 50 to 10 000 ppm of at least one optical brightener. It also relates to the resin used for forming the moulded object. It also relates to a light device combining the said moulded object with at least one artificial light source which exhibits an emission in the region of excitation of the optical brightener, in particular in the 300-450 nm range, preferably 350-420 nm range, more preferably still 350-400 nm range.
  [FR] L'invention concerne un objet moulé à base de plastique transparent et coloré présentant un effet polychromatique. Le plastique transparent comprend entre 0,1 et 1500 ppm d'au moins un colorant fluorescent et entre 50 et 10 000 ppm d'au moins un brillant optique. L'invention concerne également la résine utilisée pour former l'objet moulé, ainsi qu'un dispositif d'éclairage combinant ledit objet moulé et au moins une source lumineuse artificielle qui présente une émission dans la zone d'excitation du brillant optique, en particulier dans la gamme comprise entre 300 et 450 nm, de préférence entre 350 et 420 nm et de préférence encore entre 350 et 400 nm.
• [EN] A COSMETIC COMPOSITION INCLUDING AT LEAST ONE FLUOROPHORE COMPOUND<br/>[FR] COMPOSITION COSMÉTIQUE COMPRENANT AU MOINS UN COMPOSÉ FLUOROPHORE
  申请人：OREAL

  公开号：WO2011089571A2

  公开（公告）日：2011-07-28

  The present invention provides a cosmetic composition comprising: • a first fluorophore compound having an absorption spectrum; and • a second fluorophore compound having an emission spectrum overlapping the absorption spectrum of the first fluorophore compound, at least one of the two fluorophore compounds having luminescence enhanced by a proximity interaction effect with at least one metal, the metal and the fluorophore compound belonging to one and the same particle.