N-[(2-methyl-1H-indol-3-yl)(4-methylphenyl)methyl]pyridin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-[(2-methyl-1H-indol-3-yl)(4-methylphenyl)methyl]pyridin-2-amine
• 英文别名: N-[(2-methyl-1H-indol-3-yl)-(4-methylphenyl)methyl]pyridin-2-amine
• 化学式: C₂₂H₂₁N₃
• 分子量: 327.4
• InChiKey: CWBHEIWNECIDTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• VITAMIN D RECEPTOR-COREGULATOR INHIBITORS
  申请人：Arnold Alexander E.

  公开号：US20140194472A1

  公开（公告）日：2014-07-10

  Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.
• US9416104B2
  申请人：——

  公开号：US9416104B2

  公开（公告）日：2016-08-16
• [EN] VITAMIN D RECEPTOR - COREGULATOR INHIBITORS<br/>[FR] INHIBITEURS DE RÉCEPTEUR DE VITAMINE D - CO-RÉGULATEUR
  申请人：UWM RES FOUNDATION INC

  公开号：WO2013032960A2

  公开（公告）日：2013-03-07

  Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.