2-Cyclohex-2-en-1-yloxy-5-methylbenzaldehyde | 1131341-47-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-Cyclohex-2-en-1-yloxy-5-methylbenzaldehyde
• CAS: 1131341-47-3
• 化学式: C₁₄H₁₆O₂
• 分子量: 216.28
• InChiKey: CGSNPFDCRIKWJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3-茚满二酮 、 2-Cyclohex-2-en-1-yloxy-5-methylbenzaldehyde 在 K-10 Montmorillonite clay 作用下， 反应 0.03h， 生成 (1S,9R,13S,24R)-4-methyl-8,14-dioxahexacyclo[11.10.1.02,7.09,24.015,23.016,21]tetracosa-2(7),3,5,15(23),16,18,20-heptaen-22-one 、
  参考文献：
  名称：

  Microwave-Assisted K-10 Montmorillonite Clay–Mediated Knoevenagel Hetero-Diels–Alder Reactions: A Novel Protocol for the Synthesis of Polycyclic Pyrano[2,3,4-kl]xanthene Derivatives

  摘要：

  The intramolecular hetero-Diels-Alder reactions of 2-(cyclohex-2-enyloxy)benzaldehyde by Knoevenagel condensation with symmetrical 1,3-diones under three different conditions afforded the pyrano[2,3,4-kl]xanthene derivatives in a stereoselective manner in good yield. The structure of one of the products was unambiguously established by x-ray analysis.

  DOI：

  10.1080/00397910802417825
• 作为产物：
  描述：

  2-羟基-4-甲基苯甲醛 、 3-溴环己烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 5.5h， 以54%的产率得到2-Cyclohex-2-en-1-yloxy-5-methylbenzaldehyde
  参考文献：
  名称：

  Microwave-Assisted K-10 Montmorillonite Clay–Mediated Knoevenagel Hetero-Diels–Alder Reactions: A Novel Protocol for the Synthesis of Polycyclic Pyrano[2,3,4-kl]xanthene Derivatives

  摘要：

  The intramolecular hetero-Diels-Alder reactions of 2-(cyclohex-2-enyloxy)benzaldehyde by Knoevenagel condensation with symmetrical 1,3-diones under three different conditions afforded the pyrano[2,3,4-kl]xanthene derivatives in a stereoselective manner in good yield. The structure of one of the products was unambiguously established by x-ray analysis.

  DOI：

  10.1080/00397910802417825