tert-butyl N-[(4R,4aS,7R,7aR,12bS)-9-[N,N'-bis[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]oxy-4a-methoxy-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: tert-butyl N-[(4R,4aS,7R,7aR,12bS)-9-[N,N'-bis[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]oxy-4a-methoxy-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate
• 化学式: C₄₀H₆₀N₆O₁₁
• 分子量: 800.9
• InChiKey: LPSIEHJPCKUYEO-AZZXUMBESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  57
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  202
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• Novel 6-amino-morphinan derivatives, method of manufacturing them and their application as analgesics
  申请人：ALCASYNN PHARMACEUTICALS GMBH

  公开号：EP1762569A1

  公开（公告）日：2007-03-14

  This invention relates to a class of 6-amino-morphinan compounds which can be used as highly active analgesics. This invention also relates to their pharmaceutically acceptable salts and easily accessible derivatives (e.g. esters or amides of the amino acid derivatives), to a process for their manufacture and their application in the manufacture of pharmaceutical specialities.

  本发明涉及一类6-氨基吗啡烷化合物，可用作高效的镇痛剂。本发明还涉及它们的药学上可接受的盐和易于获取的衍生物（例如氨基酸衍生物的酯或酰胺），以及它们的制造过程和在制造药品专业用途中的应用。
• 6-Aminomorphinane derivatives, method for production and use thereof
  申请人：Schutz Johannes

  公开号：US20050038061A1

  公开（公告）日：2005-02-17

  This invention relates to compounds of the formula (I).

  本发明涉及公式（I）的化合物。
• 6-Aminomorphinane Derivatives, Method for the Production and Use Thereof
  申请人：SCHUTZ Johannes

  公开号：US20090209570A1

  公开（公告）日：2009-08-20

  This invention relates to compounds of the formula (I).

  这项发明涉及公式（I）的化合物。
• 6-AMINOMORPHINANDERIVATE, HERSTELLUNGSVERFAHREN DAFÜR UND DEREN VERWENDUNG
  申请人：ALCASYNN PHARMACEUTICALS GMBH

  公开号：EP1456212B1

  公开（公告）日：2006-12-06
• Novel 6-Amino-Morphinan Derivatives, Method of Manufacturing Them and Their Application as Analgesics
  申请人：Schuetz Johannes

  公开号：US20080234307A1

  公开（公告）日：2008-09-25

  This invention relates to a class of 6-amino-morphinan compounds of formula (I) which can be used as highly active analgesics. This invention also relates to their pharmaceutically acceptable salts and easily accessible derivatives (e.g. esters or amides of the amino acid derivatives), to a process for their manufacture and their application in the manufacture of pharmaceutical specialties.