ethyl 4-(2-methylphenylthio)-3-oxobutanoate | 83821-43-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: ethyl 4-(2-methylphenylthio)-3-oxobutanoate
• 英文别名: ethyl 4-(o-tolylthio)-3-oxobutanoate；Ethyl 4-(2-methylphenyl)sulfanyl-3-oxobutanoate
• CAS: 83821-43-6
• 化学式: C₁₃H₁₆O₃S
• 分子量: 252.334
• InChiKey: FTEUMGNSWYTHID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 4-(2-methylphenylthio)-3-oxobutanoate 在 sodium hydroxide 、 PPA 作用下， 以 水 、 氯苯 为溶剂， 生成 (7-methyl-benzo[b]thiophen-3-yl)-acetic acid
  参考文献：
  名称：

  Tominaga, Yoshinori; Pratap, Ram; Castle, Raymond N., Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 859 - 863

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯乙酰乙酸乙酯 、 2-巯基甲苯 在 三乙胺 作用下， 反应 4.0h， 生成 ethyl 4-(2-methylphenylthio)-3-oxobutanoate
  参考文献：
  名称：

  5-氰基-1,4-二氢-6-甲基-2-[[（苯磺酰基）甲基] -4-芳基-3-吡啶-羧酸乙酯和类似物的钙通道阻滞和正性肌力活性。合成和结构活性关系。

  摘要：

  描述了一系列2-[（（芳基磺酰基）甲基] -4-芳基-5-氰基-1,4-二氢吡啶-3-羧酸酯和类似物的合成和药理学评价。这些化合物具有独特的特性，即钙通道阻滞和体外正性肌力活性。选择化合物54作为该系列中最好的化合物，并进行了详细研究。还报道了54种对映异构体的合成和生物学特征。数据表明，尽管54的钙通道阻滞特性是立体定向的，但正性肌力活性不是。描述和评价了3-和6-氰基和其他紧密相关的1,4-二氢吡啶衍生物的实例以进行比较，发现它们没有上述双重活性。

  DOI：

  10.1021/jm00111a047

文献信息

• Ethyl (R)-3-hydroxy-4-phenylthiobutyrate: Synthesis by the bakers' yeast reduction and use as a precursor of enantiomerically pure β-lactam
  作者：Ryuuichirou Hayakawa、Makoto Shimizu、Tamotsu Fujisawa

  DOI：10.1016/0040-4039(96)01693-0

  日期：1996.10

  The bakers' yeast reduction of ethyl 3-oxo-4-phenylthiobutanoate gave ethyl (R)-3-hydroxy-4-phenylthiobutanoate with >99%ee. The resultant enantiomerically pure alcohol was easily transformed into β-lactam without loss of its enatiomeric purity via the oxamate derivative.

  面包师的酵母还原3-氧代-4-苯基硫代丁酸乙酯得到（R）-3-羟基-4-苯基硫代丁酸乙酯，其ee＞ 99％。所得对映体纯的醇易于通过草酸酯衍生物转化为β-内酰胺，而不会损失其对映体纯度。
• Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition
  作者：Antonella Peduto、Verena Krauth、Selene Collarile、Fiederike Dehm、Marika Ambruosi、Carmela Belardo、Francesca Guida、Antonio Massa、Veronica Esposito、Sabatino Maione、Mario de Rosa、Oliver Werz、Rosanna Filosa

  DOI：10.1016/j.ejmech.2015.11.048

  日期：2016.1

  Following the results we previously reported on a series of ethyl 2-phenylthiomethyl 5-hydroxyindole-3-carboxylate derivatives as 5-lipoxygenase (5-LOX) inhibitors, in order to obtain a more selective compound with respect to the previous generation of derivatives, we decided to modify the structure of the core ligand.The first level of structural modification involved the annelation of benzene to the indole, yielding corresponding benzo[g]indole derivatives, systematic optimization of methyl or chlorine groups in meta, ortho- and ortho/para-position of 2-phenylthiomethyl moiety were applied. The reported results show that extension of the aromatic core led to a great enhancement of activity, especially in cell-free assay, and the accurate structure-based design provided compounds 6f, 6g and 61 that block 5-LOX activity in cell-free assays with IC50 ranging from 0.17 to 0.22 mu M, and suppress 5-LOX product synthesis in polymorphonuclear leukocytes with IC50 ranging from 0.19 to 0.37 mu M. Moreover we have identified 6f and 61 as dual 5-lipoxygenase (5-LO) and microsomal prostaglandin E-2 synthase-1 (mPGES-1) inhibitors and compound 61 significantly reduces inflammatory reactions in the carrageenan-induced mouse paw oedema. The reported in vivo analysis, together with the accessible synthetic procedure, stimulate for the generation of further potent antinflammatory benzoindoles-based agents. (C) 2015 Published by Elsevier Masson SAS.