7-氧代-8-氨基壬酸 | 4707-58-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 7-氧代-8-氨基壬酸
• 中文别名: 8-氨基-7-氧代壬酸
• 英文名称: 8-amino-7-oxononanoic acid
• 英文别名: 7-Oxo-8-amino-pelargonsaeure；8-Azaniumyl-7-oxononanoate
• CAS: 4707-58-8
• 化学式: C₉H₁₇NO₃
• mdl: MFCD20547573
• 分子量: 187.239
• InChiKey: GUAHPAJOXVYFON-UHFFFAOYSA-N

物化性质

• 沸点：
  357.1±27.0 °C(Predicted)
• 密度：
  1.082±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 N-溴代丁二酰亚胺(NBS) 、 sodium cyanoborohydride 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 生成 7-氧代-8-氨基壬酸
  参考文献：
  名称：

  The mechanism of 7,8-diaminopelargonate synthase; the role of S-adenosylmethionine as the amino donor

  摘要：

  由二氨基佩拉尔戈酸（DAPA）合酶催化的反应中，第一个转氨基化步骤的产物已被证明是4-(S-腺苷)-2-氧代丁酸，该产物已被捕获为相应的醇。

  DOI：

  10.1039/b310443p

文献信息

• Functional asymmetry for the active sites of linked 5-aminolevulinate synthase and 8-amino-7-oxononanoate synthase
  作者：Tracy D. Turbeville、Junshun Zhang、W. Christopher Adams、Gregory A. Hunter、Gloria C. Ferreira

  DOI：10.1016/j.abb.2011.05.002

  日期：2011.7

  on which of the two active sites harbored the mutation. We propose that the functional asymmetry for the active sites of ALAS/ALAS stems from linking the enzyme subunits and the introduced intermolecular strain alters the protein conformational flexibility and rates of product release. Moreover, active site functional asymmetry extends to chimeric ALAS/AONS proteins, which while having a different oligomeric

  5-氨基乙酰丙酸合酶 (ALAS) 和 8-氨基-7-氧代壬酸合酶 (AONS) 是 5'-磷酸吡哆醛 (PLP) 依赖性酶的 α-氧代胺合酶家族的同型二聚体成员。以前，将两个 ALAS 亚基连接成单个多肽链二聚体产生的酶 (ALAS/ALAS) 的转换数明显高于野生型 ALAS。为了检查每个活性位点对 ALAS/ALAS 酶活性的贡献，催化性赖氨酸也与 PLP 辅因子共价结合，在活性位点之一被丙氨酸取代。尽管 ALAS/ALAS 的两个活性位点中 ALA 形成前稳态爆发的化学速率相同，但变体的 k(cat) 值显着不同（4.4±0.2 对 21.6±0.7 分钟（-1 )) 取决于两个活性位点中的哪一个含有突变。我们提出 ALAS/ALAS 活性位点的功能不对称源于连接酶亚基和引入的分子间菌株改变了蛋白质构象灵活性和产物释放速率。此外，活性位点功能不对称扩展到嵌合 ALAS/AONS 蛋
• Methods for indentifying compounds that modulate an enzyme in the coenzyme a biosynthetic pathway in a pathogenic microoganism
  申请人：Schechter M. Alan

  公开号：US20060094075A1

  公开（公告）日：2006-05-04

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

  一种通过抑制代谢途径中一个或多个酶的活性，抑制底物转化为产生次终产物或终产物的过程，特别是通过抑制途径中一个或多个酶的活性，来识别和治疗病原微生物感染的方法，以及用于抑制这些酶而抑制病原微生物感染的化合物和药物组合物。
• Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway
  申请人：Pyro Pharmaceuticals, Inc.

  公开号：US20030180830A1

  公开（公告）日：2003-09-25

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway

  一种通过抑制代谢途径中一个或多个酶的活性，从而抑制底物转化产生次终产物或最终产物，特别是通过抑制代谢途径中一个或多个酶的活性来识别和治疗病原微生物感染的方法。
• Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway and compounds and pharmaceutical compositions useful therefor
  申请人：Pyro Pharmaceuticals, Inc.

  公开号：US20040006040A1

  公开（公告）日：2004-01-08

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

  一种通过抑制代谢途径中的一个或多个酶，抑制底物转化为产生次终产物或终产物的方法，特别是通过抑制途径中一个或多个酶的活性，用于鉴定和治疗病原微生物感染，以及用于抑制这些酶的化合物和制药组合物，用于抑制病原微生物感染。
• Methods for indentifying compounds that modulate an enzyme involved in reductive carboxylation in a pathogenic microorganism
  申请人：Schechter M. Alan

  公开号：US20060178321A1

  公开（公告）日：2006-08-10

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

  一种通过抑制代谢途径中的一个或多个酶来抑制底物转化为产生次终产物或终产物的方法，特别是通过抑制途径中一个或多个酶的活性，用于鉴定和治疗病原微生物感染，以及用于抑制这些酶的化合物和制药组合物以抑制病原微生物感染的方法。