7-氨基-(4-氨基苯基)-4-羟基萘-2-磺基酸

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 7-氨基-(4-氨基苯基)-4-羟基萘-2-磺基酸
• 英文名称: 2-(4-Amino-5-hydroxy-6-methyloxan-2-yl)oxy-48-[3-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-chloro-22-[3-chloro-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-19-[[2-[4-[3,4-dihydroxy-6-methyl-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxyphenyl]-1-hydroxy-2-(methylamino)ethylidene]amino]-20,23,26,32,35,37,42,44-octahydroxy-18-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8,10,12(48),14(47),15,17(46),20,23,26,29(45),30,32,34(39),35,37,41,43,49-icosaene-40-carboxylic acid
• 英文别名: 2-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-48-[3-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-chloro-22-[3-chloro-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-19-[[2-[4-[3,4-dihydroxy-6-methyl-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxyphenyl]-1-hydroxy-2-(methylamino)ethylidene]amino]-20,23,26,32,35,37,42,44-octahydroxy-18-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8,10,12(48),14(47),15,17(46),20,23,26,29(45),30,32,34(39),35,37,41,43,49-icosaene-40-carboxylic acid
• 化学式: C₁₀₁H₁₂₁Cl₂N₉O₄₆
• 分子量: 2268.0
• InChiKey: VZHGBVYVAUUUAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.4
• 重原子数：
  158
• 可旋转键数：
  24
• 环数：
  19.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  869
• 氢给体数：
  32
• 氢受体数：
  49

文献信息

• Antibiotic-metal complexes in the detection of gram-positive bacteria and other biological analytes
  申请人：Olstein D. Alan

  公开号：US20050026813A1

  公开（公告）日：2005-02-03

  Complexes of antibiotics and metals are provided that are useful in detecting microorganisms, including gram-positive bacteria, Mycobacteria, permeabilized gram-negative bacteria, protozoans and other biological analytes, and are particularly useful in detecting gram-positive bacteria. The complexes are preferably chelated complexes wherein the antibiotic is a glycopeptide antibiotic, quinolone antibiotic, ribonucleoside antibiotic, mixtures thereof, and analogs and derivatives thereof, and (b) a detectable label comprising a transition or lanthanide metal. The complexes provide for chemiluminescent, fluorescent or magnetic detection of the analyte. Methods of synthesizing and using the complexes are also provided.

  提供了抗生素和金属的复合物，可用于检测微生物，包括革兰氏阳性菌、分枝杆菌、渗透的革兰氏阴性菌、原虫和其他生物分析物，特别是用于检测革兰氏阳性菌。复合物最好是螯合复合物，其中抗生素是糖肽类抗生素、喹诺酮类抗生素、核苷酸类抗生素、其混合物以及其类似物和衍生物，以及（b）可检测的标记，包括过渡金属或镧系金属。复合物提供了化学发光、荧光或磁性检测分析物的方法。还提供了合成和使用这些复合物的方法。