1'-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-5-methyl-5,6-dihydrospiro[imidazo[1,2-A][1,4]benzodiazepine-4,4'-piperidine]

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 1'-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-5-methyl-5,6-dihydrospiro[imidazo[1,2-A][1,4]benzodiazepine-4,4'-piperidine]
• 英文别名: [1-(4-methoxyphenyl)cyclopropyl]-(5-methylspiro[6H-imidazo[1,2-a][1,4]benzodiazepine-4,4'-piperidine]-1'-yl)methanone
• 化学式: C₂₇H₃₀N₄O₂
• mdl: MFCD29003813
• 分子量: 442.6
• InChiKey: WYAHCIUEKBLCJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Compositions and methods for the inhibition of pruritus
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：US11324725B2

  公开（公告）日：2022-05-10

  Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising a molecular inhibitor of Npr1.

  本发明公开了包含 Npr1 分子抑制剂的药物组合物。还公开了治疗、减轻或预防哺乳动物急性和/或慢性瘙痒症的方法，包括施用包含 Npr1 分子抑制剂的药物组合物。
• COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Serv

  公开号：US20190135804A1

  公开（公告）日：2019-05-09

  Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising a molecular inhibitor of Npr1.