2,2-Dichloro-2-nitro-N-o-tolyl-acetamide | 134538-88-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2-Dichloro-2-nitro-N-o-tolyl-acetamide
• 英文别名: Acetamide, 2,2-dichloro-2-nitro-N-(2-methylphenyl)-；2,2-dichloro-N-(2-methylphenyl)-2-nitroacetamide
• CAS: 134538-88-8
• 化学式: C₉H₈Cl₂N₂O₃
• 分子量: 263.08
• InChiKey: SVXQQUVYYUYPDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  dichloronitroacetyl chloride 、 邻甲苯胺 以 1,2-二氯乙烷 为溶剂， 反应 1.0h， 以73%的产率得到2,2-Dichloro-2-nitro-N-o-tolyl-acetamide
  参考文献：
  名称：

  Methods of preparation of halonitroacetic acid derivatives and study of the fungicidal activity of their amides and anilides on Sclerotinia sclerotiorum

  摘要：

  Anilides (II)-(XIII), (XV), (XVI), (XIX), and chloronitroacetamide (XVIII) were obtained in a yield of 38-90% by ammonolysis of the corresponding dichloro- (I) and chloronitroacetyl chlorides (XIV). Dichloronitroacetanilides (II), (V), ethyl (XX), propyl (XXI) esters and amide of dichloronitroacetic acid (XXII) were obtained by chlorination of anhydrous ammonium and sodium salts by sulfuryl chloride in absolute ether. Bromination of anhydrous salts of bromo- and chloronitroacetic acids proceeds readily in absolute alcohol. The yields of the bromination [(XXIII)-(XXVIII)] and chlorination products were 49-99%. Results are given of tests of some of the amides and anilides obtained for the inhibition of growth and development of the Sclerotinia sclerotiorum fungus.

  DOI：

  10.1007/bf00958561

文献信息

• YURTANOV, A. I.;ANUFRIEV, V. I.;KULISH, E. V.;MIXAJLYUCHENKO, I. G.;SHULY+, IZV. AN CCCP. CEP. XIM.,(1991) N, S. 823-830
  作者：YURTANOV, A. I.、ANUFRIEV, V. I.、KULISH, E. V.、MIXAJLYUCHENKO, I. G.、SHULY+

  DOI：——

  日期：——
• Methods of preparation of halonitroacetic acid derivatives and study of the fungicidal activity of their amides and anilides on Sclerotinia sclerotiorum
  作者：A. I. Yurtanov、V. I. Anufriev、E. V. Kulish、N. G. Mikhailyuchenko、I. I. Shulyak

  DOI：10.1007/bf00958561

  日期：1991.4

  Anilides (II)-(XIII), (XV), (XVI), (XIX), and chloronitroacetamide (XVIII) were obtained in a yield of 38-90% by ammonolysis of the corresponding dichloro- (I) and chloronitroacetyl chlorides (XIV). Dichloronitroacetanilides (II), (V), ethyl (XX), propyl (XXI) esters and amide of dichloronitroacetic acid (XXII) were obtained by chlorination of anhydrous ammonium and sodium salts by sulfuryl chloride in absolute ether. Bromination of anhydrous salts of bromo- and chloronitroacetic acids proceeds readily in absolute alcohol. The yields of the bromination [(XXIII)-(XXVIII)] and chlorination products were 49-99%. Results are given of tests of some of the amides and anilides obtained for the inhibition of growth and development of the Sclerotinia sclerotiorum fungus.