4-<3-(N-Ethyl-N-methylamino)propyl>morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-<3-(N-Ethyl-N-methylamino)propyl>morpholine
• 英文别名: N-ethyl-N-methyl-3-morpholin-4-ylpropan-1-amine
• 化学式: C₁₀H₂₂N₂O
• 分子量: 186.297
• InChiKey: QKAAVGWWSCJKCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-<1-(Benzotriazol-1-yl)-3-(morpholin-4-yl)propyl>-N-methylacetamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以89%的产率得到4-<3-(N-Ethyl-N-methylamino)propyl>morpholine
  参考文献：
  名称：

  Additions of 1-(.alpha.-Aminoalkyl)benzotriazoles to N-Vinylamines and N-Vinylamides. A Novel and Versatile Method for the Preparation of Unsymmetrically Substituted 1,3-Diamines

  摘要：

  Additions of N,N-dialkyl-1H-benzotriazole-1-methanamines 1 to 9-vinylcarbazole followed by reduction of the adducts with lithium aluminum hydride gave the corresponding 9-(3-(dialkylamino)propyl)carbazoles 8 in good yield. Treatment of the adducts with Grignard reagents gave products 9 with an alkyl or aryl group at the C-1 atom of the propylene linkage. Use of alpha-phenyl-N,N-dialkyl-1H-benzotriazole-1-methanamine (14) in the addition led to the C-3 phenyl substituted products 15-18. Similar additions to N-vinyl-N-methylacetamide or 1-vinyl-2-pyrrolidinone followed by reduction of the adducts gave unsymmetrically substituted 1,3-propanediamines. Triamine 36 was obtained by condensation of ethylamine with formaldehyde and benzotriazole, addition of the product to 1-vinylpyrrolidinone, and reduction of the adduct with lithium aluminum hydride. 1,3-Propanediamine used in this process gave hexahydropyrimidine 39 while 1,6-hexanediamine gave hexamine 42.

  DOI：

  10.1021/jo00097a023

文献信息

• Thiazolyl-Benzimidazoles
  申请人：Cai Jianping

  公开号：US20100160308A1

  公开（公告）日：2010-06-24

  The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.

  这项发明涉及到式（1）的化合物及其药用可接受盐，其制备方法和使用方法。
• Biaryltriazole inhibitors of macrophage migration inhibitory factor
  申请人：YALE UNIVERSITY

  公开号：US10336721B2

  公开（公告）日：2019-07-02

  The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory diseases and cancer.

  本公开介绍了双芳基三唑化合物及其组合物和使用方法。这些化合物抑制巨噬细胞迁移抑制因子的活性，可用于治疗疾病，如炎症性疾病和癌症。
• Katritzky Alan R., Rachwal Stanislaw, Rachwal Bogumila, J. Org. Chem, 59 (1994) N 18, S 5206-5214
  作者：Katritzky Alan R., Rachwal Stanislaw, Rachwal Bogumila

  DOI：——

  日期：——
• 6-MORPHOLINYL-2-PYRAZOLYL-9H-PURINE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP3277682B1

  公开（公告）日：2019-04-24
• BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR
  申请人：YALE UNIVERSITY

  公开号：US20180179176A1

  公开（公告）日：2018-06-28

  The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory diseases and cancer.