N-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]-2-furamide | 1372552-93-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]-2-furamide
• 英文别名: N-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]furan-2-carboxamide
• CAS: 1372552-93-6
• 化学式: C₁₉H₂₂N₂O₃
• 分子量: 326.395
• InChiKey: SOUFKEDKBSUQKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  71.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  糠酸（呋喃甲酸） 、 异氰环已烷 、 三苯甲醛缩二胺 以 甲苯 为溶剂， 反应 12.0h， 以0.32 g的产率得到N-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]-2-furamide
  参考文献：
  名称：

  Catalyst-Free Synthesis of α-Aminoacyl-amides via N,N′-Bis(Phenylmethylidene)phenylmethanediamine as Imine Surrogate in Ugi Multicomponent Reaction

  摘要：

  A novel one-pot, multicomponent, and catalyst-free reaction of N,N'-bis(phenylmethylidene)phenylmethane, carboxylic acids, and isocyanides yielding alpha-aminoacyl-amides is described. The reaction is based on the combination of an Ugi three-component reaction followed by hydrolysis.

  DOI：

  10.1080/00397911.2010.529229

文献信息

• Catalyst-Free Synthesis of <font>α</font>-Aminoacyl-amides via <i>N,N</i>′-Bis(Phenylmethylidene)phenylmethanediamine as Imine Surrogate in Ugi Multicomponent Reaction
  作者：Abdolali Alizadeh、Javad Mokhtari

  DOI：10.1080/00397911.2010.529229

  日期：2012.3.1

  A novel one-pot, multicomponent, and catalyst-free reaction of N,N'-bis(phenylmethylidene)phenylmethane, carboxylic acids, and isocyanides yielding alpha-aminoacyl-amides is described. The reaction is based on the combination of an Ugi three-component reaction followed by hydrolysis.