Bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazol-2-yl)methane

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: Bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazol-2-yl)methane
• 英文别名: 2-(4,8b-dihydro-3aH-indeno[1,2-d][1,3]oxazol-2-ylmethyl)-4,8b-dihydro-3aH-indeno[1,2-d][1,3]oxazole
• 化学式: C₂₁H₁₈N₂O₂
• 分子量: 330.4
• InChiKey: BDHSVQLSNIGJNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  43.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazol-2-yl)methane 、 5’-O-(4,4’-二甲氧基三苯甲基)尿苷 、 异氰酸苯酯 、 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-phenylcarbamoyluridine 在 Copper(II) trifluoromethanesulfonate 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-O-phenylcarbamoyluridine were produced at the ratio of 82:18的产率得到5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-phenylcarbamoyl-uridine
  参考文献：
  名称：

  2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF

  摘要：

  本发明涉及一种通过在存在铜化合物和光学活性配体组成的金属配合物的条件下，将核苷与酰化试剂反应，制备2'-羟基保护核苷衍生物的方法。根据本发明的方法，可以从未保护2'、3'-羟基的核苷衍生物中，以良好的区域选择性轻松地制备出2'-羟基保护的核苷衍生物，该衍生物是合成寡核苷酸的重要中间体。

  公开号：

  US20110009609A1

文献信息

• [EN] A PROCESS FOR THE SYNTHESIS OF CARBON LABELED ORGANIC COMPOUNDS<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE COMPOSÉS ORGANIQUES MARQUÉS AU CARBONE
  申请人：COMMISSARIAT ENERGIE ATOMIQUE

  公开号：WO2019193068A1

  公开（公告）日：2019-10-10

  The present invention relates to a process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group. The present invention also concerns the use of carbon labeled organic compounds containing a carbon labeled carboxyl group obtained by the process of the invention, in the manufacture of pharmaceuticals and agrochemicals, in particular pharmaceuticals and agrochemicals having a free carboxylic acid functionality. Another aspect of the invention relates to a process for manufacturing labeled pharmaceuticals and agrochemicals, in particular pharmaceuticals and agrochemicals having a free carboxylic acid functionality, comprising a step of synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl obtained by the process of the invention A still another aspect of the invention further relates to a process for producing tracers and radiotracers, characterized in that it comprises a step of synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group obtained by the process of the invention.

  本发明涉及一种合成含有碳标记羧基的碳标记有机化合物的方法。本发明还涉及使用通过本发明方法获得的含有碳标记羧基的碳标记有机化合物，在制药和农药制造中的应用，特别是在具有自由羧基酸功能的制药和农药中的应用。发明的另一个方面涉及一种制造标记制药品和农药的方法，特别是制造具有自由羧基酸功能的制药品和农药的方法，包括通过本发明方法获得的含有碳标记羧基的碳标记有机化合物的合成步骤。发明的另一个方面进一步涉及一种生产示踪剂和放射示踪剂的方法，其特点在于包括通过本发明方法获得的含有碳标记羧基的碳标记有机化合物的合成步骤。
• 2′-hydroxy-protected ribonucleoside derivative and production method thereof
  申请人：Kaneka Corporation

  公开号：US08252919B2

  公开（公告）日：2012-08-28

  The present invention relates to a method for producing a 2′-hydroxy-protected nucleoside derivative by reacting a ribonucleoside with an acylating or a carbamoylating reagent in the presence of a metal complex consisting of a copper compound and an optically active ligand. By the method according to the present invention, a 2′-hydroxy-protected ribonucleoside derivative, which is an important intermediate for producing an oligonucleoside, can be easily produced with good regioselectivity from a nucleoside derivative of which 2′,3′-hydroxy groups are not protected.

  本发明涉及一种通过在铜化合物和手性配体的存在下，将核苷与酰化或氨基甲酰化试剂反应以制备2'-羟基保护核苷衍生物的方法。通过本发明的方法，可以从未保护2'、3'羟基的核苷衍生物中轻松地制备出2'-羟基保护的核苷衍生物，这是制备寡核苷酸的重要中间体，且具有良好的区域选择性。
• A PROCESS FOR THE SYNTHESIS OF CARBON LABELED ORGANIC COMPOUNDS
  申请人：Commissariat à l'Energie Atomique et aux Energies Alternatives

  公开号：EP3549927A1

  公开（公告）日：2019-10-09

  The present invention relates to a process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group. The present invention also concerns the use of carbon labeled organic compounds containing a carbon labeled carboxyl group obtained by the process of the invention, in the manufacture of pharmaceuticals and agrochemicals, in particular pharmaceuticals and agrochemicals having a free carboxylic acid functionality. Another aspect of the invention relates to a process for manufacturing labeled pharmaceuticals and agrochemicals, in particular pharmaceuticals and agrochemicals having a free carboxylic acid functionality, comprising a step of synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl obtained by the process of the invention A still another aspect of the invention further relates to a process for producing tracers and radiotracers, characterized in that it comprises a step of synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group obtained by the process of the invention.

  本发明涉及一种合成含有碳标记羧基的碳标记有机化合物的工艺。 本发明还涉及将通过本发明工艺获得的含有碳标记羧基的碳标记有机化合物用于制造药物和农用化学品，特别是具有游离羧酸官能团的药物和农用化学品。 本发明的另一方面涉及一种制造标记药物和农用化学品，特别是具有游离羧酸官能团的药物和农用化学品的工艺，包括合成含有本发明工艺获得的碳标记羧基的碳标记有机化合物的步骤。 本发明的另一个方面还涉及一种生产示踪剂和放射性示踪剂的工艺，其特征在于该工艺包括合成通过本发明工艺获得的含有碳标记羧基的碳标记有机化合物的步骤。