2-amino-3-nitro-4-(2-thienyl)pyridine | 901130-22-1

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 2-amino-3-nitro-4-(2-thienyl)pyridine
• 英文别名: 3-nitro-4-thiophen-2-ylpyridin-2-amine
• CAS: 901130-22-1
• 化学式: C₉H₇N₃O₂S
• 分子量: 221.239
• InChiKey: JFLUEKAYLHVCHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-amino-3-nitro-4-(2-thienyl)pyridine 在 palladium 10% on activated carbon sodium tetrahydroborate 作用下， 以 乙醇 、 水 、 乙酸乙酯 为溶剂， 反应 1.0h， 以82%的产率得到4-(thiophen-2-yl)pyridine-2,3-diamine
  参考文献：
  名称：

  IMIDAZOPYRIDINE DERIVATIVE

  摘要：

  公开号：

  EP1847546B1
• 作为产物：
  描述：

  2-氨基-3-硝基-4-氯吡啶 、 2-三丁基甲锡烷基噻吩 在 bis-triphenylphosphine-palladium(II) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以93%的产率得到2-amino-3-nitro-4-(2-thienyl)pyridine
  参考文献：
  名称：

  IMIDAZOPYRIDINE DERIVATIVE

  摘要：

  公开号：

  EP1847546B1

文献信息

• METHOD FOR REPLICATING NUCLEIC ACIDS AND NOVEL UNNATURAL BASE PAIRS
  申请人：Hirao Ichiro

  公开号：US20100036111A1

  公开（公告）日：2010-02-11

  The present invention relates to a method for nucleic acid replication and novel artificial base pairs. The method of the present invention for nucleic acid replication is characterized in that a deoxyribonucleoside 5′-triphosphate, in which the hydroxyl group of phosphoric acid at the γ-position is substituted with a group selected from the group consisting of an amino group, a methylamino group, a dimethylamino group, a mercapto group and a fluoro group, is used as a substrate during replication reaction. The novel artificial base pairs of the present invention are characterized in that 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) or an analog thereof forms a base pair with pyrrole-2-carbaldehyde (Pa) or an analog thereof.

  本发明涉及一种核酸复制方法和新型人工碱基对。本发明的核酸复制方法的特征在于，在复制反应过程中使用一种脱氧核苷酸5'-三磷酸作为底物，其中磷酸γ-位置的羟基被从以下群组中选择的一种群组所取代，所述群组包括氨基、甲基氨基、二甲基氨基、巯基和氟基。本发明的新型人工碱基对的特征在于，7-(2-噻吩基)-咪唑并[4,5-b]吡啶（Ds）或其类似物与吡咯-2-甲醛（Pa）或其类似物形成一对碱基。
• Imidazopyridine Derivatives
  申请人：Hirao Ichiro

  公开号：US20080125381A1

  公开（公告）日：2008-05-29

  The present invention relates to a novel imidazo[4,5-b]pyridine derivative compound represented by Formula (I) and a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the above compound. The present invention further relates to a pharmaceutical composition comprising the above compound. The above compound has growth inhibitory activity on cancer cells, and this effect is dissociated from growth inhibitory activity on normal cells. This indicates that the compound is useful as a novel anticancer agent.

  本发明涉及一种新型咪唑并[4,5-b]吡啶衍生物化合物，其表示为公式（I），以及其药学上可接受的盐。本发明还涉及制备上述化合物的方法。本发明还涉及包含上述化合物的制药组合物。上述化合物具有对癌细胞的生长抑制活性，且该效果与对正常细胞的生长抑制活性分离。这表明该化合物可用作新型抗癌剂。
• Imidazopyridine derivatives
  申请人：Riken

  公开号：US07615628B2

  公开（公告）日：2009-11-10

  The present invention relates to a novel imidazo[4,5-b]pyridine derivative compound represented by Formula (I) and a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the above compound. The present invention further relates to a pharmaceutical composition comprising the above compound. The above compound has growth inhibitory activity on cancer cells, and this effect is dissociated from growth inhibitory activity on normal cells. This indicates that the compound is useful as a novel anticancer agent.

  本发明涉及一种新型咪唑[4,5-b]吡啶衍生物化合物，其表示为公式(I)及其药学上可接受的盐。本发明还涉及一种制备上述化合物的方法。本发明进一步涉及一种包含上述化合物的药物组合物。上述化合物对癌细胞具有生长抑制活性，且该效果与对正常细胞的生长抑制活性分离。这表明该化合物可用作一种新型抗癌剂。
• Method for nucleic acid replication and novel artificial base pairs
  申请人：Riken

  公开号：US08030478B2

  公开（公告）日：2011-10-04

  The present invention relates to a method for nucleic acid replication and novel artificial base pairs. The method of the present invention for nucleic acid replication is characterized in that a deoxyribonucleoside 5′-triphosphate, in which the hydroxyl group of phosphoric acid at the γ-position is substituted with a group selected from the group consisting of an amino group, a methylamino group, a dimethylamino group, a mercapto group and a fluoro group, is used as a substrate during replication reaction. The novel artificial base pairs of the present invention are characterized in that 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) or an analog thereof forms a base pair with pyrrole-2-carbaldehyde (Pa) or an analog thereof.

  本发明涉及一种核酸复制方法和新型人工碱基对。本发明的核酸复制方法的特征在于，在复制反应中使用一种脱氧核糖核苷酸5'-三磷酸，其中磷酸的γ-位置的羟基被从以下群组中选出的一种基团替代，所述群组包括氨基、甲基氨基、二甲基氨基、巯基和氟基。本发明的新型人工碱基对的特征在于，7-(2-噻吩基)-咪唑并[4,5-b]吡啶（Ds）或其类似物与吡咯-2-甲醛（Pa）或其类似物形成碱基对。
• METHOD FOR NUCLEIC ACID REPLICATION AND NOVEL ARTIFICIAL BASE PAIRS
  申请人：Riken

  公开号：EP1970445A1

  公开（公告）日：2008-09-17

  The present invention relates to a method for nucleic acid replication and novel artificial base pairs. The method of the present invention for nucleic acid replication is characterized in that a deoxyribonucleoside 5'-triphosphate, in which the hydroxyl group of phosphoric acid at the γ-position is substituted with a group selected from the group consisting of an amino group, a methylamino group, a dimethylamino group, a mercapto group and a fluoro group, is used as a substrate during replication reaction. The novel artificial base pairs of the present invention are characterized in that 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) or an analog thereof forms a base pair with pyrrole-2-carbaldehyde (Pa) or an analog thereof.

  本发明涉及一种核酸复制方法和新型人工碱基对。 本发明的核酸复制方法的特征在于，在复制反应中使用脱氧核苷 5'-三磷酸作为底物，其中磷酸在 γ 位上的羟基被选自氨基、甲氨基、二甲氨基、巯基和氟基的基团取代。本发明的新型人工碱基对的特征在于，7-(2-噻吩基)-咪唑并[4,5-b]吡啶（Ds）或其类似物与吡咯-2-甲醛（Pa）或其类似物形成碱基对。