3-(2-chloroethoxy)propanoyl chloride | 864296-93-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 3-(2-chloroethoxy)propanoyl chloride
• 英文别名: 3-(2-chloro-ethoxy)-propionic acid-chloride；3-(2-chloro-ethoxy)propionylchloride；3-(2-Chloroethoxy)propanoyl chloride
• CAS: 864296-93-5
• 化学式: C₅H₈Cl₂O₂
• 分子量: 171.023
• InChiKey: GFQMQYQGLZKNPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2-chloroethoxy)propanoyl chloride 、 4-氨基-3-甲基苯甲酸甲酯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.83h， 以41%的产率得到methyl 4-[3-(2-chloro-ethoxy)-propionyl-amino]-3-methyl-benzoate
  参考文献：
  名称：

  [DE] NEUE CARBONSÄUREAMIDE ALS FAKTOR XA-INHIBITOREN
  [EN] NOVEL CARBOXAMIDES FOR USE AS XA INHIBITORS
  [FR] NOUVEAUX CARBOXAMIDES COMME INHIBITEURS DU FACTEUR XA

  摘要：

  The subject of the present invention is new substituted carboxylic acid amides of the general formula (I), in which A, B, and R1 to R5 are as defined in claim 1, their tautomers, their enantiomers, their diastereomers, their mixtures, and their salts, especially their physiologically acceptable salts with inorganic or organic acids or bases, which have valuable properties. The compounds have an antithrombotic effect and are Factor Xa inhibitors.

  公开号：

  WO2005082895A1
• 作为产物：
  描述：

  氯-一聚乙二醇-酸 在 氯化亚砜 作用下， 生成 3-(2-chloroethoxy)propanoyl chloride
  参考文献：
  名称：

  NEW I-ARYLPIPERAZINIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF

  摘要：

  该发明涉及一类新的化合物，能够高亲和力和选择性地抑制5-HT7受体。该发明还涉及将这类化合物用作药物，用于治疗和预防中枢神经系统与5-HT7受体相关的疾病。该发明还涉及同位素标记的化合物，用于体内诊断或成像5-HT7状况。

  公开号：

  US20140086834A1

文献信息

• New carboxylic acid amides, the preparation thereof and their use as medicaments
  申请人：Priepke Henning

  公开号：US20050203078A1

  公开（公告）日：2005-09-15

  The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R 1 to R 5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

  本发明涉及一般式的新取代羧酸酰胺 其中A、B和R1至R5如权利要求1中定义，其互变异构体、对映体、非对映异构体、它们的混合物及其盐，特别是其与无机或有机酸或碱形成的生理上可接受的盐，具有有价值的性质。
• [EN] NEW 1-ARYLPIPERAZINIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF<br/>[FR] NOUVEAUX LIGANDS 1-ARYLPIPÉRAZINIQUES DE RÉCEPTEUR 5-HT7 ET UTILISATION DE CEUX-CI
  申请人：UNIV BARI

  公开号：WO2012159662A1

  公开（公告）日：2012-11-29

  The invention relates to a new class of compounds able to inhibit with high affinity and selectivity the 5-HT7 receptor. The invention also relates to the utilization of such compounds as medicaments useful in the treatment and prevention of 5-HT7 receptor relating disorders of the central nervous system. The invention also relates to the isotopically labeled compounds for use in vivo diagnosis or imaging of a 5-HT7 condition.

  这项发明涉及一类新的化合物，能够以高亲和力和选择性抑制5-HT7受体。该发明还涉及将这类化合物用作药物，用于治疗和预防中枢神经系统与5-HT7受体相关的疾病。该发明还涉及同位素标记的化合物，用于体内诊断或成像5-HT7状况。
• NEW CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS
  申请人：PRIEPKE Henning

  公开号：US20080146539A1

  公开（公告）日：2008-06-19

  The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

  本发明涉及一种新的取代羧酸酰胺，其一般式为其中A、B和R1至R5如权利要求1所定义，其互变异构体、对映异构体、顺反异构体、混合物及其与无机或有机酸或碱的生理上可接受的盐，具有有价值的性质。
• Carboxylic acid amides, the preparation thereof and their use as medicaments
  申请人：Boehringer Ingelheim International GmbH

  公开号：US07947700B2

  公开（公告）日：2011-05-24

  The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

  本发明涉及一种具有有价值性质的新取代羧酸酰胺，其一般式为其中A、B和R1至R5如权利要求1所定义，其互变异构体、对映异构体、顺反异构体、其混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐。
• CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS
  申请人：PRIEPKE Henning

  公开号：US20130237522A1

  公开（公告）日：2013-09-12

  The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

  本发明涉及新的取代羧酸酰胺，其一般式为 A、B 和 R1 到 R5 如权利要求1所定义，其互变异构体、对映异构体、顺反异构体、混合物及其与无机或有机酸或碱的生理上可接受的盐，具有有价值的性质。