2-Bromo-6-(5,6,7-trimethoxy-indan-1-yl)-cyclohepta-2,4,6-trienone | 224299-46-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-Bromo-6-(5,6,7-trimethoxy-indan-1-yl)-cyclohepta-2,4,6-trienone
• 英文别名: 2-bromo-6-(5,6,7-trimethoxy-2,3-dihydro-1H-inden-1-yl)cyclohepta-2,4,6-trien-1-one
• CAS: 224299-46-1
• 化学式: C₁₉H₁₉BrO₄
• 分子量: 391.261
• InChiKey: BOZGJNALOLSZHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甲胺 、 2-Bromo-6-(5,6,7-trimethoxy-indan-1-yl)-cyclohepta-2,4,6-trienone 生成 2-Methylamino-6-(5,6,7-trimethoxy-indan-1-yl)-cyclohepta-2,4,6-trienone
  参考文献：
  名称：

  The synthesis and evaluation of temperature sensitive tubulin toxins

  摘要：

  The synthesis of several potent inhibitors of tubulin polymerization that exert their activities through interaction at the colchicine binding site is described. These agents were evaluated for their abilities to inhibit the polymerization of tubulin and the growth of neoplastic cell cultures. Additionally, the inhibition of tubulin polymerization activity of these agents was assessed over a temperature range of 30-45 degrees C to ascertain the effect of temperature on this activity. Several of the compounds possess significant inhibition of tubulin polymerization activity, and select compounds exhibit this activity in a temperature dependent manner. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00747-1
• 作为产物：
  描述：

  1-(7,7-Dibromo-1-methoxy-bicyclo[4.1.0]hept-3-en-3-yl)-5,6,7-trimethoxy-indan 在 吡啶 、 dimethoxydioxirane*H₂O 作用下， 生成 2-Bromo-6-(5,6,7-trimethoxy-indan-1-yl)-cyclohepta-2,4,6-trienone
  参考文献：
  名称：

  The synthesis and evaluation of temperature sensitive tubulin toxins

  摘要：

  The synthesis of several potent inhibitors of tubulin polymerization that exert their activities through interaction at the colchicine binding site is described. These agents were evaluated for their abilities to inhibit the polymerization of tubulin and the growth of neoplastic cell cultures. Additionally, the inhibition of tubulin polymerization activity of these agents was assessed over a temperature range of 30-45 degrees C to ascertain the effect of temperature on this activity. Several of the compounds possess significant inhibition of tubulin polymerization activity, and select compounds exhibit this activity in a temperature dependent manner. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00747-1

文献信息

• The synthesis and evaluation of temperature sensitive tubulin toxins
  作者：Thomas A. Miller、Amanda L. Bulman、Charles D. Thompson、Timothy L. Macdonald

  DOI：10.1016/s0960-894x(98)00747-1

  日期：1999.2

  The synthesis of several potent inhibitors of tubulin polymerization that exert their activities through interaction at the colchicine binding site is described. These agents were evaluated for their abilities to inhibit the polymerization of tubulin and the growth of neoplastic cell cultures. Additionally, the inhibition of tubulin polymerization activity of these agents was assessed over a temperature range of 30-45 degrees C to ascertain the effect of temperature on this activity. Several of the compounds possess significant inhibition of tubulin polymerization activity, and select compounds exhibit this activity in a temperature dependent manner. (C) 1999 Elsevier Science Ltd. All rights reserved.