indole thioether

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: indole thioether
• 英文别名: 1H-indole;sulfane
• 化学式: 2C₈H₇N*H₂S
• 分子量: 268.382
• InChiKey: CCGNIYCPGXLHNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.28
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  16.8
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• BROAD SPECTRUM PHARMACOLOGICAL COMPOSITION FOR TREATMENTOF VARIOUS INFECTIONS AND DISEASES AND METHODSOF USE
  申请人：Uddin Naeem

  公开号：US20160199329A1

  公开（公告）日：2016-07-14

  A pharmacological composition for the treatment of bacterial and protozoal infections in a patient. The preferred pharmacological composition comprises a pharmaceutical carrier and an active composition selected from the group consisting of: a) an amount of sodium oxalate and an amount of oxalic acid, b) an amount of sodium citrate and an amount of citric acid, or c) mixtures of a) and b). The amounts and weight ratios of a) the sodium oxalate and oxalic acid, and b) the sodium citrate and citric acid in the active composition are such as to produce a safe and effective pharmacological composition. Sodium salts of other carboxylic acids may be used. The invention also relates to the method of using the pharmacological composition for the safe and effective treatment of bacterial infections, protozoal infections and dermatological diseases.

  一种用于治疗患者的细菌和原虫感染的药物组合物。首选的药物组合物包括药用载体和从以下组中选择的活性成分：a）一定量的草酸钠和一定量的草酸，b）一定量的柠檬酸钠和一定量的柠檬酸，或c）a）和b）的混合物。活性成分中a）草酸钠和草酸的数量和重量比例，以及b）柠檬酸钠和柠檬酸的数量和重量比例，是为了产生安全有效的药物组合物。其他羧酸的钠盐也可以使用。本发明还涉及使用药物组合物以安全有效地治疗细菌感染，原虫感染和皮肤病的方法。
• Bacterium of Bacillus genus and uses thereof
  申请人：DCM Shriram Ltd.

  公开号：US10327448B2

  公开（公告）日：2019-06-25

  The present work relates to a novel microbe belonging to Bacillus family exhibiting antimicrobial and/or antifungal and plant growth promoting activity. The present work relates to the method of its isolation and identifying extract of the novel microbe exhibiting antimicrobial and/or antifungal, plant growth promoting proteolytic amylolytie activities. In particular, there is provided a novel bacterium Bacillus subtilis ssp. shriramensis having accession number MTCC-5674. The novel bacterium is cultured in the medium to mass produce the antimicrobial and/or antifungal and plant growth promoting agent by the novel microbe and Sin the culture medium. There is provided a composition comprising the novel bacterium or an extract of the novel bacterium, which is agriculturally and pharmaceutically effective. The novel bacterium of the present work is used in the treatment against various pathogenic fungi and/or bacteria and promoting growth plants.

  本研究涉及一种属于芽孢杆菌科的新型微生物，该微生物具有抗菌和/或抗真菌以及促进植物生长的活性。本工作涉及其分离和鉴定新型微生物提取物的方法，该提取物具有抗菌和/或抗真菌、促进植物生长的蛋白水解淀粉酶活性。特别是提供了一种新型枯草芽孢杆菌（Bacillus subtilis ssp. Shriramensis），其登录号为 MTCC-5674。新型细菌在培养基中培养，通过新型微生物和 Sin 培养基大量生产抗菌剂和/或抗真菌剂以及植物生长促进剂。本发明提供了一种包含该新型细菌或该新型细菌提取物的组合物，该组合物具有农业和药学效果。本作品中的新型细菌可用于治疗各种病原真菌和/或细菌，并促进植物生长。
• Broad spectrum pharmacological composition for treatment of various infections and diseases and methods of use
  申请人：Uddin Naeem

  公开号：US10646461B2

  公开（公告）日：2020-05-12

  A pharmacological composition for the treatment of bacterial and protozoal infections in a patient. The preferred pharmacological composition comprises a pharmaceutical carrier and an active composition selected from the group consisting of: a) an amount of sodium oxalate and an amount of oxalic acid, b) an amount of sodium citrate and an amount of citric acid, or c) mixtures of a) and b). The amounts and weight ratios of a) the sodium oxalate and oxalic acid, and b) the sodium citrate and citric acid in the active composition are such as to produce a safe and effective pharmacological composition. Sodium salts of other carboxylic acids may be used. The invention also relates to the method of using the pharmacological composition for the safe and effective treatment of bacterial infections, protozoal infections and dermatological diseases.

  一种用于治疗患者细菌和原生动物感染的药物组合物。优选的药理组合物包括药物载体和选自以下组别的活性组合物：a) 一定量的草酸钠和一定量的草酸，b) 一定量的柠檬酸钠和一定量的柠檬酸，或 c) a) 和 b) 的混合物。a) 草酸钠和草酸，以及 b) 柠檬酸钠和柠檬酸在活性组合物中的用量和重量比可以产生安全有效的药用组合物。也可使用其他羧酸的钠盐。本发明还涉及使用该药理组合物安全有效地治疗细菌感染、原生动物感染和皮肤病的方法。
• NOVEL BACTERIUM OF BACILLUS GENUS AND USES THEREOF
  申请人：DCM Shriram Ltd.

  公开号：EP3180420A1

  公开（公告）日：2017-06-21
• BACTERIUM OF BACILLUS SUBTILIS SSP. SHRIRAMENSIS AND USES THEREOF
  申请人：DCM Shriram Ltd.

  公开号：EP3180420B1

  公开（公告）日：2020-10-21