7-phenylimidazo<1,2-a>pyridine | 39573-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-phenylimidazo<1,2-a>pyridine
• 英文别名: 7-Phenyl-<1,2-a>imidazopyrimidin；2-Phenylimidazo<1,2-a>pyrimidin；7-Phenyl-imidazolo<1,2-a>pyrimidin；7-phenyl-imidazo[1,2-a]pyrimidine；7-Phenylimidazo[1,2-a]pyrimidine
• CAS: 39573-70-1
• 化学式: C₁₂H₉N₃
• mdl: MFCD09994599
• 分子量: 195.224
• InChiKey: KQYBPMIOQQEIEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯基锂 、 咪唑并[1,2-a]嘧啶 在 丙醛 作用下， 生成 7-phenylimidazo<1,2-a>pyridine
  参考文献：
  名称：

  Reactivity of Phenyllithium toward Bridgehead Nitrogen Heterocycles

  摘要：

  The reactivity of phenyllithium toward some bridgehead nitrogen heterocycles was investigated. Imidazo[1,2-a]pyridine gave the substitution, while other series gave addition reactions. In addition, the ring opening derivative was obtained in imidazo[1,2-c]quinazoline series.

  DOI：

  10.3987/com-93-6581

文献信息

• AEROSOLIZED NITRITE AND NITRIC OXIDE - DONATING COMPOUNDS AND USES THEREOF
  申请人：Aires Pharmaceuticals, Inc.

  公开号：EP2237788A2

  公开（公告）日：2010-10-13
• US5037980A
  申请人：——

  公开号：US5037980A

  公开（公告）日：1991-08-06
• [EN] AEROSOLIZED NITRITE AND NITRIC OXIDE - DONATING COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS PERMETTANT D'OBTENIR DU NITRITE ET DE L'OXYDE NITRIQUE AÉROSOLISÉS ET LEURS UTILISATIONS
  申请人：AIRES PHARMACEUTICALS INC

  公开号：WO2009086470A2

  公开（公告）日：2009-07-09

  Disclosed herein are formulations of nitrite, nitrite salt, or nitrite- or nitric oxide-producing compounds suitable for aerosolization and use of such formulations for aerosol administration of nitrite, nitrite salt, or nitrite- or nitric oxide-donating compounds for the treatment of pulmonary arterial hypertension, intra-nasal or pulmonary bacterial infections, or to treat or prevent ischemic reperfusion injury of the heart, brain and organs involved in transplantation. In particular, inhaled nitrite, nitrite salt, or nitrite- or nitric oxide-donating compound specifically formulated and delivered to the respiratory tract for the indications is described. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures and manufacturing processes for production and use of the compositions described.
• Reactivity of Phenyllithium toward Bridgehead Nitrogen Heterocycles
  作者：Alain Gueiffier、Henri Viols、Yves Blache、Olivier Chavignon、Jean Claude Teulade、Andr� Aumelas、Jean-Pierre Chapat

  DOI：10.3987/com-93-6581

  日期：——

  The reactivity of phenyllithium toward some bridgehead nitrogen heterocycles was investigated. Imidazo[1,2-a]pyridine gave the substitution, while other series gave addition reactions. In addition, the ring opening derivative was obtained in imidazo[1,2-c]quinazoline series.